In vitro oxidative stress regulatory potential of Citrullus colocynthis and Tephrosia apollinea

• Published in: Acta Pharmaceutica Vol. 68; no. 2; pp. 235 - 242
• Main Authors: Rizvi, Tania Shamim, Khan, Abdul Latif, Ali, Liaqat, Al-Mawali, Narjis, Mabood, Fazal, Hussain, Javid, Adnan, Muhammad, Al-Harrasi, Ahmed
• Format: Journal Article Web Resource
• Language: English
• Published: Croatia De Gruyter Open 01.06.2018; De Gruyter Poland; Hrvatsko farmaceutsko društvo; Sciendo
• Subjects: Antioxidants; Antioxidants - isolation & purification; Antioxidants - metabolism; Antioxidants - pharmacology; Biological activity; Butanol; Chloroform; Citrullus colocynthis; Citrullus colocynthis - chemistry; Free Radical Scavengers - isolation & purification; Free Radical Scavengers - pharmacology; Glutathione; Glutathione - metabolism; Herbal medicine; Leaves; Lipid peroxidation; Lipid Peroxidation - drug effects; Lipids; Medicinal plants; n-Hexane; Organs; Oxidative stress; Oxidative Stress - drug effects; Peroxidation; Phenolic compounds; Phenols; Phenols - isolation & purification; Plant Extracts - chemistry; Plant Extracts - pharmacology; Reactive oxygen species; Reactive Oxygen Species - metabolism; Scavenging; Tephrosia; Tephrosia - chemistry; Tephrosia apollinea; total phenolics; Tephrosia apollinea; total phenolics; Citrullus colocynthis; oxidative stress
• ISSN: 1846-9558; 1330-0075; 1846-9558
• DOI: 10.2478/acph-2018-0012

The present study investigates the potential role of medicinal plants and in ameliorating the oxidative stress developed during the generation of reactive oxygen species. Organic extracts of different organs (leaf, stem and root) of these medicinal plants obtained in -hexane, chloroform, -butanol and water were assayed for radical scavenging, total antioxidant capacity, anti-lipid peroxidation and reduced glutathione. The total phenolic content (TPC) of both selected medicinal plants was also evaluated. The results indicated that extracts of . leaf, stem and root have higher TPC compared to those of . Similarly, the results of the present study revealed higher bioactivity of than that of . in various antioxidant assays. Various plant parts of each plant were also compared.