Positive Selection in F-Box Domain (lpp0233) Encoded in Legionella pneumophila Strains

• Published in: Biocontrol Science Vol. 23; no. 2; pp. 53 - 59
• Main Authors: KENZAKA, TAKEHIKO, YASUI, MADOKA, BABA, TAKASHI, NASU, MASAO, TANI, KATSUJI
• Format: Journal Article
• Language: English
• Published: Japan The Society for Antibacterial and Antifungal Agents, Japan 2018; Japan Science and Technology Agency
• Subjects: Amino Acid Substitution; Bacterial Proteins - genetics; Biological evolution; Computational Biology; Eukaryotes; Eukaryotic like protein; Evolution, Molecular; Evolutionary genetics; F-box; Gene sequencing; Genes; Genetics; Genomes; Hot spring; Hot springs; Hot Springs - microbiology; Legionella pneumophila; Legionella pneumophila - genetics; Legionella pneumophila - isolation & purification; Legionnaires' disease bacterium; Multiplication; Mutation, Missense; Nonsynonymous substitution; Point Mutation; Positive selection; Protein Domains; Proteins; Selection, Genetic; Substitutes; Hot spring; Legionella pneumophila; F-box; Nonsynonymous substitution; Eukaryotic like protein
• ISSN: 1342-4815; 1884-0205
• DOI: 10.4265/bio.23.53

Recent studies have shown that the genome of Legionella pneumophila is characterized by many foreign genes from a variety of eukaryotes. The eukaryotic like proteins are known to play a role in its multiplication within host cells; however, their evolutionary genetics of L. pneumophila in environments is unknown. In this study, we examined the nonsynonymous/synonymous substitution rate of eukaryotic like domain encoding genes among L. pneumophila strains. In silico analysis revealed that the nonsynonymous/synonymous substitution rate in F-box domain gene (lpp0233) was higher than those in other eukaryotic like domain and protein encoding genes and housekeeping genes. The F-box domain gene sequences in L. pneumophila strains isolated from a natural hot spring were more diversified than those of previously known strains, owing to preferential positive selection.