Novel cell-based therapies in inflammatory bowel diseases: the established concept, promising results

• Published in: Human cell : official journal of Human Cell Research Society Vol. 34; no. 5; pp. 1289 - 1300
• Main Authors: Hossein-khannazer, Nikoo, Torabi, Shukoofeh, Hosseinzadeh, Ramin, Shahrokh, Shabnam, Asadzadeh Aghdaei, Hamid, Memarnejadian, Arash, Kadri, Nadir, Vosough, Massoud
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 01.09.2021; Springer Nature B.V
• Subjects: Antigen-Presenting Cells; Biomedical and Life Sciences; Bowel disease; Cell Biology; Cell therapy; Cell- and Tissue-Based Therapy - methods; Cell- and Tissue-Based Therapy - trends; Chronic Disease; Clinical trials; Dendritic Cells; Emerging markets; Gynecology; Hematopoietic Stem Cells; Humans; Inflammatory bowel diseases; Inflammatory Bowel Diseases - therapy; Intestine; Life Sciences; Medicin och hälsovetenskap; Mesenchymal Stem Cells; Oncology; Quality of life; Remission; Reproductive Medicine; Review; Review Article; Stem Cells; Surgery; T-Lymphocytes, Regulatory; Immune therapy; Inflammatory bowel diseases; Cell therapy; Cell-based products
• ISSN: 1749-0774; 0914-7470; 1749-0774
• DOI: 10.1007/s13577-021-00560-w

Inflammatory bowel diseases (IBDs) are chronic and relapsing disorders that affect the quality of life in many individuals around the world. Over the past few years, the prevalence of IBDs is substantially rising which might pose a considerable social and economic burden on health systems. Progresses in the management of chronic inflammatory diseases lead to prolonged remission phase and decreased hospitalization rate. However, during treatment, many patients become refractory to conventional therapies. Recently, advanced approaches using somatic cell therapy medicinal products (SCTMPs) including immune and stem cell-based therapies have drawn many researchers’ attentions. Promising results from recent trials, alongside with the emerging market indicated that these therapeutic approaches could be an alternative and promising treatment to conventional therapies. In this review, we will discuss recent advances in cell-based therapies, which have been developed for treatment of IBDs. In addition, the global emerging market and the novel products in this field are highlighted.