Transcriptome Profiling Reveals Differential Expression of Circadian Behavior Genes in Peripheral Blood of Monozygotic Twins Discordant for Parkinson's Disease

• Published in: Cells (Basel, Switzerland) Vol. 11; no. 16; p. 2599
• Main Authors: Semenova, Ekaterina I, Vlasov, Ivan N, Partevian, Suzanna A, Rosinskaya, Anna V, Rybolovlev, Ivan N, Slominsky, Petr A, Shadrina, Maria I, Alieva, Anelya Kh
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.08.2022; MDPI
• Subjects: Apoptosis; Biopsy; Blood; Circadian rhythms; Data analysis; Development and progression; DNA methylation; Dopamine; Environmental conditions; Fibroblasts; Gene expression; Gene Expression Profiling; Genetic aspects; Health aspects; Humans; Metabolism; monozygotic twins; Movement disorders; Mutation; Neurodegenerative diseases; Oxidative stress; Parkinson Disease - genetics; Parkinson's disease; Pathogenesis; Peripheral blood; Repressor Proteins - genetics; RNA; Trans-Activators - genetics; Transcriptomes; Twins; Twins, Monozygotic - genetics; whole transcriptome analysis; Russia; United States > US; Netherlands; whole transcriptome analysis; monozygotic twins; peripheral blood; circadian rhythms; Parkinson’s disease; gene expression
• ISSN: 2073-4409; 2073-4409
• DOI: 10.3390/cells11162599

Parkinson's disease (PD) is one of the most common neurodegenerative diseases. Investigating individuals with the most identical genetic background is optimal for minimizing the genetic contribution to gene expression. These individuals include monozygotic twins discordant for PD. Monozygotic twins have the same genetic background, age, sex, and often similar environmental conditions. The aim of this study was to carry out a transcriptome analysis of the peripheral blood of three pairs of monozygotic twins discordant for PD. We identified the metabolic process "circadian behavior" as a priority process for further study. Different expression of genes included in the term "circadian behavior" confirms that this process is involved in PD pathogenesis. We found increased expression of three genes associated with circadian behavior, i.e., , , and , in twins with PD. These genes can be considered as potential candidate genes for this disease.