Polydioxanone Membrane Compared with Collagen Membrane for Bone Regeneration

• Published in: Polymers Vol. 15; no. 4; p. 868
• Main Authors: Quirino, Lilian Caldas, de Azambuja Carvalho, Pedro Henrique, Neto, Renato Torres Augusto, Comachio, Cássio Amaro, Monteiro, Naara Gabriela, Ervolino-Silva, Ana Cláudia, Okamoto, Roberta, Pereira-Filho, Valfrido Antonio
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.02.2023; MDPI
• Subjects: Acids; Animals; Biocompatibility; Biomedical materials; bone regeneration; Bones; By products; Calcium phosphates; Collagen; Connective tissues; Crystalline polymers; Defects; Ethylenediaminetetraacetic acid; Gas industry; Gene expression; Grafting; Hydroxyapatite; membrane; Membranes; Microtomography; Penicillin G; polydioxanone; Polymers; Regeneration (physiology); Skin & tissue grafts; Substitute bone; synthetic polymer; Tissue engineering; Transplants & implants; Vascular endothelial growth factor; Brazil; United Kingdom; synthetic polymer; bone regeneration; polydioxanone; membrane
• ISSN: 2073-4360; 2073-4360
• DOI: 10.3390/polym15040868

Guided bone regeneration (GBR) is an approach that induces osteopromotion through the regenerative membranes. These barriers exhibit bioactive behavior and mechanical function. Polydioxanone is a synthetic option, already used in medicine and dentistry, with good results in bone regeneration. This study aimed to evaluate bone repair in critical defects in rat calvaria using a polydioxanone membrane (Plenum Guide) compared with a commercially available collagen-based membrane (Bio-Gide ). The bone defects were filled with Plenum Oss , a synthetic bone graft, hydroxyapatite:β-tricalcium phosphate, 70:30%, Group PG (Plenum Guide + Plenum Oss ), and Group BG (Geistlich Bio-Gide + Plenum Oss ). The specimens were submitted to immunohistochemical (RUNX2 and OPN), gene expression (RUNX2, IBSP, and VEGF), histometric, and microtomography analyses after 07, 15, 30, and 60 days postoperative. PG group showed greater immunolabeling area for RUNX2 and OPN, higher gene expression of VEGF (3.15 ± 0.85), and IBSP (24.9 ± 0.59). However, there was no statistical difference between groups in the histometric analysis regarding the percentage of connective tissue PG (0.83 ± 0.45), BG (0.70 ± 0.34), neoformed bone PG (0.60 ± 0.4), BG (0.65 ± 0.51), and remaining biomaterial PG (0.84 ± 0.31), BG (0.91 ± 0.33). In addition, there was no statistical difference between groups by micro-CT analysis. The absorbable-synthetic membrane, Plenum Guide, is an effective membrane for guided bone regeneration.