Genetic marker polymorphisms on chromosome 8q24 and prostate cancer in the Dutch population: DG8S737 may not be the causative variant

• Published in: European journal of human genetics : EJHG Vol. 19; no. 1; pp. 118 - 120
• Main Authors: Zeegers, Maurice P, Khan, Humera S, Schouten, Leo J, van Dijk, Boukje A C, Goldbohm, R Alexandra, Schalken, Jack, Shajahan, Shahin, Pearlman, Alexander, Oddoux, Carole, van den Brandt, Piet A, Ostrer, Harry
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.01.2011; Nature Publishing Group
• Subjects: 631/208/2489/144/68; 631/208/721; 692/699/67/589/466; Alleles; Bioinformatics; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Case-Control Studies; Chromosome 8; Chromosomes; Chromosomes, Human, Pair 8 - genetics; Classical genetics, quantitative genetics, hybrids; Cytogenetics; Epidemiology; European Continental Ancestry Group - genetics; Fundamental and applied biological sciences. Psychology; Gene Expression; General aspects. Genetic counseling; Genetic diversity; Genetic markers; Genetic Predisposition to Disease; Genetics of eukaryotes. Biological and molecular evolution; Genomes; Haplotypes; Health risk assessment; Human; Human Genetics; Humans; Male; Medical genetics; Medical sciences; Microsatellite Repeats - genetics; Middle Aged; Molecular and cellular biology; Mutation; Nephrology. Urinary tract diseases; Netherlands; Polymorphism, Genetic; Population; Prostate; Prostate cancer; Prostatic Neoplasms - genetics; Prostatic Neoplasms - pathology; Public health; Risk groups; Short Report; Single-nucleotide polymorphism; Statistical analysis; Studies; Tumors; Tumors of the urinary system; Urinary tract. Prostate gland; White people; Netherlands; Europe; New York; United Kingdom > UK; United States > US; epidemiology; cancer; prostatic neoplasm/genetics; SNP; microsatellite repeats/genetics; Chromosomal aberration; Genetic mapping; Human; Prostate tumor; Urinary system disease; Prostate disease; Genetic marker; Repeated sequence; Aneuploidy; Malignant tumor; Epidemiology; Variant; Microsatellite DNA; Supernumerary chromosome; Genetics; Population; Single nucleotide polymorphism; Male genital diseases; Prostate cancer; Dutch; Cancer; prostatic neoplasms/genetics; microsatellite/SNP/genetics
• ISSN: 1018-4813; 1476-5438; 1476-5438
• DOI: 10.1038/ejhg.2010.133

Prostate cancer is the most commonly diagnosed cancer in men in Europe and Northern America. Genome-wide association studies (GWAS) have detected an association with markers on chromosome 8q24. Allele -8 of microsatellite DG8S737 with 22 repeats and allele A of the single-nucleotide polymorphism (SNP) rs1447295 have been found to be significantly associated with prostate cancer. As GWAS are subjected to type 1 error, confirmation studies are required to validate the results. Here, we analysed the same markers in 277 cases and 282 controls from the Netherlands using a nested case–control study. Incident prostate cancer cases and controls selected were identified in the population of the Netherlands Cohort Study. We also investigated clinical features of the disease by stratifying by tumour stage. We did not replicate the association with the SNP rs1447295-A allele ( P =0.10), although the effect estimate was in the same direction as previous studies (odds ratio (OR), 1.38). Interestingly a statistically significant decreased risk was observed for DG8S737 allele -8 (OR, 0.62; P =0.03). The apparent protective effect of the DG8S737 -8 allele observed in this study contrasts with the Amundadottir study. This suggests that DG8S737 and rs1447295 might be tightly linked markers flanking the actual causative variant and that there may be potentially more than one high-risk haplotype present in the Caucasian population. This short report highlights the importance of validation, although further confirmation is still needed.