Anti-inflammation activities of essential oil and its constituents from indigenous cinnamon ( Cinnamomum osmophloeum) twigs

• Published in: Bioresource technology Vol. 99; no. 9; pp. 3908 - 3913
• Main Authors: Tung, Yu-Tang, Chua, Meng-Thong, Wang, Sheng-Yang, Chang, Shang-Tzen
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.06.2008; [New York, NY]: Elsevier Ltd; Elsevier Science
• Subjects: acetates; Acrolein; Acrolein - analogs & derivatives; Acrolein - pharmacology; analogs & derivatives; Animals; Anti-inflammation; anti-inflammatory activity; Anti-Inflammatory Agents; Anti-Inflammatory Agents - pharmacology; Biological and medical sciences; biosynthesis; Cell Death; Cell Death - drug effects; Cell Line; chemical composition; chemistry; Cinnamomum; Cinnamomum - chemistry; Cinnamomum - drug effects; Cinnamomum osmophloeum; cinnamon; Curcumin; Curcumin - pharmacology; Dinoprostone; Dinoprostone - biosynthesis; drug effects; Essential oil; essential oils; eugenol; Fundamental and applied biological sciences. Psychology; Humans; lipopolysaccharides; Lipopolysaccharides - pharmacology; macrophages; Mice; nitric oxide; Nitric Oxide - biosynthesis; Oils, Volatile; Oils, Volatile - chemistry; Oils, Volatile - pharmacology; pharmacology; prostaglandins; trans-Cinnamaldehyde; Twigs; Essential oil; Twigs; Cinnamomum osmophloeum; trans-Cinnamaldehyde; Anti-inflammation; Cinnamaldehyde; Antiinflammatory agent; Woody plant; Dicotyledones; Angiospermae; Spermatophyta; Cinnamomum; Lauraceae
• ISSN: 0960-8524; 1873-2976
• DOI: 10.1016/j.biortech.2007.07.050

In this study, chemical compositions of hydrodistilled essential oil and anti-inflammatory activities from the twigs of Cinnamomum osmophloeum Kaneh. were investigated for the first time. The chemical constituents of the twig essential oil were further analyzed by GC–MS and they were found to be l-bornyl acetate (15.89%), caryophyllene oxide (12.98%), γ-eudesmol (8.03%), β-caryophyllene (6.60%), T-cadinol (5.49%), δ-cadinene (4.79%), trans-β-elemenone (4.25%), cadalene (4.19%), and trans-cinnamaldehyde (4.07%). The effects of essential oil on nitric oxide (NO) and prostaglandin E 2 (PGE 2) production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages were also examined. Results of nitric oxide tests indicated that twig essential oil and its major constituents such as trans-cinnamaldehyde, caryophyllene oxide, l-borneol, l-bornyl acetate, eugenol, β-caryophyllene, E-nerolidol, and cinnamyl acetate have excellent activities. These findings demonstrated that essential oil of C. osmophloeum twigs have excellent anti-inflammatory activities and thus have great potential to be used as a source for natural health products.