Long-Term Mortality in a Cohort of Home-Dwelling Elderly with Mild Alzheimer's Disease and Lewy Body Dementia

• Published in: Dementia and geriatric cognitive disorders Vol. 38; no. 3-4; pp. 161 - 169
• Main Authors: Oesterhus, Ragnhild, Soennesyn, Hogne, Rongve, Arvid, Ballard, Clive, Aarsland, Dag, Vossius, Corinna
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland Karger 01.01.2014; S. Karger AG
• Subjects: Adult and adolescent clinical studies; Age Factors; Aged; Aged, 80 and over; Alzheimer Disease - mortality; Biological and medical sciences; Cohort Studies; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Dementia; Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology; Female; Humans; Lewy Body Disease - mortality; Longitudinal Studies; Male; Medical sciences; Medicin och hälsovetenskap; Middle Aged; Neurology; Non tumoral diseases; Norway; Organic mental disorders. Neuropsychology; Original Research Article; Otorhinolaryngology. Stomatology; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Residence Characteristics; Survival Rate; Norway; Standardized mortality ratio; Mortality; Lewy body dementia; Alzheimer's disease; Survival; Dementia with Lewy bodies; Dementia; Human; Nervous system diseases; Cognitive disorder; Alzheimer disease; Lewy body disease; Cerebral disorder; Central nervous system disease; Degenerative disease; Elderly
• ISSN: 1420-8008; 1421-9824; 1421-9824
• DOI: 10.1159/000358051

Objective: To study mortality in subjects with mild dementia in Norway with a special focus on patients with Lewy body dementia (LBD) compared to Alzheimer's disease (AD). Methods: All referrals of mild dementia patients to dementia clinics in western Norway from March 2005 to March 2007 were included and followed until December 2012. Diagnoses were based on a comprehensive standardized assessment program. Results: Of 209 patients, 137 (66%) had AD and 53 (25%) had LBD. Dementia was associated with increased mortality (standardized mortality ratio = 1.8, AD 1.5, LBD 2.6). The median survival time was 6.2 years (95% CI 5.4-6.9). Predictors of mortality were age at diagnosis (HR 1.1 per year) and LBD diagnosis (HR 2.4). Conclusion: Dementia patients had an increased mortality, particularly those with LBD.