Increased program cell death-1 expression on T lymphocytes of patients with progressive multifocal leukoencephalopathy

• Published in: Journal of acquired immune deficiency syndromes (1999) Vol. 60; no. 3; p. 244
• Main Authors: Tan, Chen Sabrina, Bord, Evelyn, Broge, Jr, Thomas A, Glotzbecker, Brett, Mills, Heidi, Gheuens, Sarah, Rosenblatt, Jacalyn, Avigan, David, Koralnik, Igor J
• Format: Journal Article
• Language: English
• Published: United States 01.07.2012
• Subjects: Adult; Aged; Aged, 80 and over; AIDS-Related Opportunistic Infections - complications; AIDS-Related Opportunistic Infections - immunology; AIDS-Related Opportunistic Infections - virology; Case-Control Studies; CD4-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - virology; Female; HIV Infections - complications; HIV Infections - immunology; HIV Infections - virology; Humans; Immunity, Cellular; JC Virus - immunology; Leukoencephalopathy, Progressive Multifocal - complications; Leukoencephalopathy, Progressive Multifocal - immunology; Leukoencephalopathy, Progressive Multifocal - virology; Male; Middle Aged; Programmed Cell Death 1 Receptor - antagonists & inhibitors; Programmed Cell Death 1 Receptor - metabolism; Young Adult
• ISSN: 1944-7884
• DOI: 10.1097/QAI.0b013e31825a313c

The cellullar immune response is important in the containment of progressive multifocal leukoencephalopathy (PML). We examined program cell death-1 (PD-1) expression, a marker of cellular immune exhaustion, on T lymphocytes in PML. PD-1 expression was elevated on total CD4(+) and CD8(+) T cells (medians 36% and 24%) in PML patients compared with healthy control subjects (medians 14% and 18%; P = 0.0015 and P = 0.033). In PML patients, JC virus (JCV)-specific CD8(+) cytotoxic T lymphocytes expressed PD-1 more frequently than total CD8 T lymphocytes (means 39% and 78%, P = 0.0004). Blocking the PD-1 receptor increased JCV-specific T-cell immune response in a subgroup of PML patients.