The biodegradation mechanism of calcium phosphate biomaterials in bone

This study was undertaken to understand the biodegradation mechanisms of calcium phosphate (Ca-P) biomaterials with different crystallization. Two types of sintered Ca-P porous ceramic (HA and beta-TCP) and a Ca-P bone cement (CPC) were implanted into cavities drilled in rabbit femoral and tibiae co...

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Bibliographic Details
Published inJournal of biomedical materials research Vol. 63; no. 4; p. 408
Main Authors Lu, Jianxi, Descamps, Michel, Dejou, Jacques, Koubi, Gilles, Hardouin, Pierre, Lemaitre, Jacques, Proust, Jean-Pierre
Format Journal Article
LanguageEnglish
Published United States 2002
Subjects
Animals
Biocompatible Materials - chemistry
Biocompatible Materials - metabolism
Biodegradation, Environmental
Bone Cements - chemistry
Bone Cements - metabolism
Bone Substitutes - chemistry
Bone Substitutes - metabolism
Calcium Phosphates - metabolism
Calcium Phosphates - therapeutic use
Femur - cytology
Femur - surgery
Macrophages
Materials Testing
Osteoblasts
Phagocytosis
Rabbits
Tibia - cytology
Tibia - surgery
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Summary:This study was undertaken to understand the biodegradation mechanisms of calcium phosphate (Ca-P) biomaterials with different crystallization. Two types of sintered Ca-P porous ceramic (HA and beta-TCP) and a Ca-P bone cement (CPC) were implanted into cavities drilled in rabbit femoral and tibiae condyles. The results have shown that a material biodegradation was rapid in the beta-TCP and the CPC, but very weak in the HA. This biodegradation presented a decrease of material volume from the periphery to the center as well as a particle formation causing phagocytosis by numerous macrophages and multinucleated giant cells in the CPC. In the beta-TCP, there was a peripheral and central decrease of material volume as well as an absence of particle formation or visible phagocytosis. The process of biodegradation is considered to be directly influenced by the type of material crystallization. The sintered bioceramics processed at a high temperature exhibit good crystallization and are primarily degraded by a process dependent on interstitial liquids. However, the bone cement is formed by physicochemical crystallization and is degraded through a dissolution process associated with a cellular process.
ISSN:0021-9304
DOI:10.1002/jbm.10259