A Convenient Synthetic Protocol to 1,2-Bis(dialkylphosphino)ethanes

1,2‐Bis(dialkylphosphino)ethanes are readily prepared from the parent phosphine oxides, via a novel sodium aluminium hydride/sodium hydride reduction protocol of intermediate chlorophosphonium chlorides. This approach is amenable to multi‐gram syntheses, utilises readily available and inexpensive re...

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Bibliographic Details
Published inAdvanced synthesis & catalysis Vol. 356; no. 2-3; pp. 603 - 608
Main Authors Doyle, Laurence R., Heath, Alex, Low, Choon Heng, Ashley, Andrew E.
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 10.02.2014
WILEY‐VCH Verlag
Wiley
Subjects
Aluminium
Aluminum
Catalysis
Chemistry
Chemistry, Applied
Chemistry, Organic
Chlorides
Hydrides
Parents
phosphane ligands
Physical Sciences
reduction
Science & Technology
Sodium
Synthesis
synthetic methods
Updates
hydrides
ELECTRON-RICH
ACTIVATION
TERTIARY
HYDRIDE
PHOSPHORUS LIGANDS
phosphane ligands
aluminium
II COMPLEXES
PHOSPHINE-BORANE COMPLEXES
OXIDES
reduction
CARBON-DIOXIDE
synthetic methods
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Summary:1,2‐Bis(dialkylphosphino)ethanes are readily prepared from the parent phosphine oxides, via a novel sodium aluminium hydride/sodium hydride reduction protocol of intermediate chlorophosphonium chlorides. This approach is amenable to multi‐gram syntheses, utilises readily available and inexpensive reagents, and benefits from a facile non‐aqueous work‐up in the final reductive step.
Bibliography:Funded Access
Royal Commission for the Exhibition of 1851
ark:/67375/WNG-CB4PZGWP-T
istex:702B82CE79BC7BC8909245D2376F97CA831927EA
Royal Society - No. University Research Fellowship
ArticleID:ADSC201300787
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201300787