Implications of the global increase of diabetes for tuberculosis control and patient care

• Published in: Tropical medicine & international health Vol. 15; no. 11; pp. 1289 - 1299
• Main Authors: Ruslami, Rovina, Aarnoutse, Rob E, Alisjahbana, Bachti, Van Der Ven, Andre J.A.M, Van Crevel, Reinout
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.11.2010; Blackwell
• Subjects: Adult; Aged; Aged, 80 and over; Antitubercular Agents - adverse effects; Antitubercular Agents - therapeutic use; Bacterial diseases; Biological and medical sciences; control de la tuberculosis; Developing Countries; Diabetes; Diabetes Complications - epidemiology; Diabetes Complications - prevention & control; Diabetes Mellitus - drug therapy; Diabetes Mellitus - epidemiology; Diabetes. Impaired glucose tolerance; diabète; Disease control; Drug Interactions; Drug therapy; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Epidemics; epidemiology; epidemiología; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; General aspects; Human bacterial diseases; Humans; Hypoglycemic Agents - adverse effects; Hypoglycemic Agents - therapeutic use; Infectious diseases; lutte contre la tuberculose; Male; Medical sciences; Middle Aged; Mycobacterium; Opportunistic Infections - epidemiology; Opportunistic Infections - prevention & control; Systematic review; Tuberculosis; Tuberculosis - epidemiology; Tuberculosis - prevention & control; Tuberculosis and atypical mycobacterial infections; tuberculosis control; Young Adult; épidémiologie; Endocrinopathy; Human; Diabetes mellitus; Check; Mycobacterial infection; Epidemiology; Infection; Prevention; Tuberculosis; tuberculosis control; Bacteriosis; Tropical medicine; diabetes
• ISSN: 1360-2276; 1365-3156
• DOI: 10.1111/j.1365-3156.2010.02625.x

Objectives To review the current knowledge about tuberculosis (TB) and diabetes, assessing the implication of the global increase of diabetes for TB control and patient care. Methods Systematic literature review. Results Using public databases, it can be estimated that 12.6% (95% CI 9.2-17.3%) of new TB cases in the 10 countries with the highest TB burden will be attributable to TB in 2030, a relative increase of 25.5% compared to 2010. Diabetes is associated with a higher age and body weight among patients with TB, but probably not with a specific clinical presentation of TB. Rifampicin hampers glycemic control by increasing the metabolism of most oral antidiabetic drugs, while diabetes patients may have lower concentrations of anti‐TB drugs. This might be one factor contributing to higher TB treatment failure rates. Conclusions The global epidemic of diabetes has implications for control and treatment of TB. Prospective studies are needed to improve prevention, early detection and treatment of concomitant diabetes and TB, especially in developing countries.