Argentine population genetic structure: Large variance in Amerindian contribution

• Published in: American journal of physical anthropology Vol. 132; no. 3; pp. 455 - 462
• Main Authors: Seldin, Michael F., Tian, Chao, Shigeta, Russell, Scherbarth, Hugo R., Silva, Gabriel, Belmont, John W., Kittles, Rick, Gamron, Susana, Allevi, Alberto, Palatnik, Simon A., Alvarellos, Alejandro, Paira, Sergio, Caprarulo, Cesar, Guillerón, Carolina, Catoggio, Luis J., Prigione, Cristina, Berbotto, Guillermo A., García, Mercedes A., Perandones, Carlos E., Pons-Estel, Bernardo A., Alarcon-Riquelme, Marta E.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.03.2007; Wiley-Liss
• Subjects: Admixture; Amerindians; Ancestry; Ancestry informative markers; Argentina; Asian People - genetics; Bayes Theorem; Black People - genetics; Data analysis; Evolutionary anthropology; Excavation and methods; Field method; Gene Frequency; Genetic Markers; Genetic Variation; Genetics; Genetics, Population; Humans; Indians, South American - genetics; MEDICIN; MEDICINE; Methodology and general studies; Mexican Americans - genetics; Physical anthropology; Population; Population stratification; Prehistory and protohistory; Survey; White People - genetics; Amerindian; Europe; Africa; Cartography; Study; admixture; Genetic; Human palaeontology; population stratification; Ethnology; Method; Weight; Case; ancestry informative markers; Analysis; Individual; Population
• ISSN: 0002-9483; 1096-8644; 1096-8644
• DOI: 10.1002/ajpa.20534

Argentine population genetic structure was examined using a set of 78 ancestry informative markers (AIMs) to assess the contributions of European, Amerindian, and African ancestry in 94 individuals members of this population. Using the Bayesian clustering algorithm STRUCTURE, the mean European contribution was 78%, the Amerindian contribution was 19.4%, and the African contribution was 2.5%. Similar results were found using weighted least mean square method: European, 80.2%; Amerindian, 18.1%; and African, 1.7%. Consistent with previous studies the current results showed very few individuals (four of 94) with greater than 10% African admixture. Notably, when individual admixture was examined, the Amerindian and European admixture showed a very large variance and individual Amerindian contribution ranged from 1.5 to 84.5% in the 94 individual Argentine subjects. These results indicate that admixture must be considered when clinical epidemiology or case control genetic analyses are studied in this population. Moreover, the current study provides a set of informative SNPs that can be used to ascertain or control for this potentially hidden stratification. In addition, the large variance in admixture proportions in individual Argentine subjects shown by this study suggests that this population is appropriate for future admixture mapping studies. Am J Phys Anthropol, 2007. © 2006 Wiley‐Liss, Inc.