RELATIONSHIPS BETWEEN CYTOSKELETAL PROTEINS AND THE TOXIC EFFECTS OF DRUGS

Many cell functions and aspects of cell configuration are linked with changes in cytoskeletal proteins, by intracellular signal transduction. Histochemical and pathophysiological changes caused by toxins or drugs affect on dynamic aspects of cytoskeletal proteins. Here we review that biochemical and...

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Bibliographic Details
Published inJournal of toxicological sciences Vol. 22; no. 5; pp. 383 - 395
Main Authors TSUYAMA, Shingo, TAKENAKA, Shigeo
Format Journal Article
LanguageEnglish
Published Tokyo The Japanese Society of Toxicology 1997
Japanese Society of Toxicology
Japan Science and Technology Agency
Subjects
Actin Cytoskeleton - drug effects
Animals
Biological and medical sciences
Cytoskeletal Proteins - ultrastructure
Drug toxicity and drugs side effects treatment
Drug-Related Side Effects and Adverse Reactions
Medical sciences
Microtubules - drug effects
Miscellaneous (drug allergy, mutagens, teratogens...)
Pharmacology. Drug treatments
Signal Transduction - drug effects
Drug
Cell function
Toxicity
Chemical compound
Microfilament
Cytotoxicity
Intermediate filament
Signal transduction
Cell component
Cytoskeleton
Intracellular
Microtubule
Mechanism of action
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Summary:Many cell functions and aspects of cell configuration are linked with changes in cytoskeletal proteins, by intracellular signal transduction. Histochemical and pathophysiological changes caused by toxins or drugs affect on dynamic aspects of cytoskeletal proteins. Here we review that biochemical and molecular biological properties of the microtubules and microfilaments and the relationships between these cytoskeletal proteins and the toxic effects of drugs and toxins. The intracellular signaling pathway makes use of cytoskeletal proteins.
ISSN:0388-1350
1880-3989
DOI:10.2131/jts.22.5_383