Features of Extramedullary Disease of Multiple Myeloma: High Frequency of P53 Deletion and Poor Survival: A Retrospective Single-Center Study of 834 Cases

Micro-Abstract Extramedullary disease (EMD) of multiple myeloma (MM) can develop at the time of diagnosis or during follow-up, and exhibits different clinical features. Our analysis of 834 consecutive MM patients showed that EMD was remarkably related with P53 deletion, determined using fluorescence...

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Published inClinical lymphoma, myeloma and leukemia Vol. 15; no. 5; pp. 286 - 291
Main Authors Deng, Shuhui, Xu, Yan, An, Gang, Sui, Weiwei, Zou, Dehui, Zhao, Yaozhong, Qi, Junyuan, Li, Fei, Hao, Mu, Qiu, Lugui
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.05.2015
Subjects
Adult
Aged
Aged, 80 and over
Disease Progression
Extramedullary disease
Female
Gene Frequency
Hematology, Oncology and Palliative Medicine
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Multiple myeloma
Multiple Myeloma - genetics
Multiple Myeloma - mortality
Multiple Myeloma - pathology
Multivariate Analysis
Mutation
P53 deletion
Prognosis
Proportional Hazards Models
Retrospective Studies
Treatment Outcome
Tumor Suppressor Protein p53 - genetics
Prognosis
Extramedullary disease
Multiple myeloma
P53 deletion
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Summary:Micro-Abstract Extramedullary disease (EMD) of multiple myeloma (MM) can develop at the time of diagnosis or during follow-up, and exhibits different clinical features. Our analysis of 834 consecutive MM patients showed that EMD was remarkably related with P53 deletion, determined using fluorescence in situ hybridization analysis, and a dismal prognosis.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:2152-2650
2152-2669
DOI:10.1016/j.clml.2014.12.013