Zoonotic aspects of arenavirus infections

• Published in: Veterinary microbiology Vol. 140; no. 3; pp. 213 - 220
• Main Authors: Charrel, R.N., de Lamballerie, X.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 27.01.2010; Amsterdam; New York: Elsevier; Elsevier
• Subjects: Africa, Western - epidemiology; Americas - epidemiology; Animals; Arenaviridae; Arenaviridae Infections - epidemiology; Arenaviridae Infections - transmission; Arenaviridae Infections - veterinary; Arenaviridae Infections - virology; Arenavirus; Arenavirus - classification; Arenavirus - genetics; Arenavirus - immunology; Arenavirus - isolation & purification; Arenaviruses; central nervous system diseases; congenital abnormalities; disease reservoirs; disease transmission; Hemorrhagic Fevers, Viral - epidemiology; Hemorrhagic Fevers, Viral - transmission; Hemorrhagic Fevers, Viral - virology; host-pathogen relationships; hosts; Humans; isolation; Lassa-Lymphocytic choriomeningitis; Life Sciences; literature reviews; Meningitis, Viral - epidemiology; Meningitis, Viral - transmission; Meningitis, Viral - virology; polymerase chain reaction; Rodentia - virology; rodents; Sabia; Zoonoses; Zoonoses - epidemiology; Zoonoses - transmission; Zoonoses - virology; Americas; Africa, Western; Arenaviruses; Zoonoses
• ISSN: 0378-1135; 1873-2542
• DOI: 10.1016/j.vetmic.2009.08.027

To date, the International Committee for Taxonomy of Viruses recognizes that the family Arenaviridae contains a unique genus Arenavirus that includes 22 viral species. There are nine additional arenaviruses that either have been discovered recently, or which taxonomic status remains pending. Arenaviruses have been classified according to their antigenic properties into two groups, the Lassa-Lymphocytic choriomeningitis (LCM) serocomplex and the Tacaribe serocomplex which has been further divided into four evolutionary lineages. Each arenavirus is more or less tightly associated with a mammal host. The distribution of the host dictates the distribution of the virus. Humans may become infected by arenaviruses through direct contact with infected rodents, including bites, or through inhalation of infectious rodent excreta and secreta. Lassa, Junin, Machupo, Guanarito, and Sabia viruses are known to cause a severe hemorrhagic fever, in western Africa, Argentina, Bolivia, Venezuela, and Brazil, respectively. Infection by LCM virus can result in acute central nervous system disease, congenital malformations, and infection in organ transplantation recipients. Detection of arenaviruses in their animal host can be achieved by virus isolation, and has recently taken advantage of PCR-based techniques. The approach based on consensus degenerate primers has shown efficient for both detection of known arenaviruses, and discovery of new arenaviruses.