Functional connectivity assessed by resting state EEG correlates with cognitive decline of Alzheimer’s disease – An eLORETA study

• Published in: Clinical neurophysiology Vol. 127; no. 2; pp. 1269 - 1278
• Main Authors: Hata, Masahiro, Kazui, Hiroaki, Tanaka, Toshihisa, Ishii, Ryouhei, Canuet, Leonides, Pascual-Marqui, Roberto D, Aoki, Yasunori, Ikeda, Shunichiro, Kanemoto, Hideki, Yoshiyama, Kenji, Iwase, Masao, Takeda, Masatoshi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2016
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - diagnosis; Alzheimer Disease - physiopathology; Alzheimer’s disease; Brain - physiopathology; CDR (Clinical Dementia Rating); Cognition Disorders - diagnosis; Cognition Disorders - physiopathology; Dementia; EEG; Electroencephalography - methods; Female; Functional connectivity; Humans; Lagged phase synchronization; LORETA; Male; MMSE (Mini-Mental State Examination); Nerve Net - physiopathology; Neurology; Rest - physiology; Functional connectivity; MMSE (Mini-Mental State Examination); Alzheimer’s disease; EEG; Lagged phase synchronization; LORETA; CDR (Clinical Dementia Rating); Dementia
• ISSN: 1388-2457; 1872-8952
• DOI: 10.1016/j.clinph.2015.10.030

Highlights • Patients with Alzheimer’s disease (AD) showed decreased lagged phase synchronization in delta band between most cortical regions. • Several functional connections in delta band were shown to be associated with cognitive decline and global function in AD. • Our findings offer new insight into neurophysiological features of AD based on physiological lagged connectivity.