Brain Metastasis in Colorectal Cancer Patients: Survival and Analysis of Prognostic Factors

• Published in: Clinical colorectal cancer Vol. 14; no. 4; pp. 281 - 290
• Main Authors: Michl, Marlies, Thurmaier, Johannes, Schubert-Fritschle, Gabriele, Wiedemann, Max, Laubender, Rüdiger P, Nüssler, Natascha C, Ruppert, Reinhard, Kleeff, Jörg, Schepp, Wolfgang, Reuter, Clemens, Löhe, Florian, Karthaus, Meinolf, Neumann, Jens, Kirchner, Thomas, Engel, Jutta, Heinemann, Volker
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2015
• Subjects: Adult; Aged; Aged, 80 and over; Brain metastasis; Brain Neoplasms - diagnosis; Brain Neoplasms - pathology; Brain Neoplasms - secondary; CNS metastasis; Colorectal Neoplasms - diagnosis; Colorectal Neoplasms - pathology; Female; Gastroenterology and Hepatology; Hematology, Oncology and Palliative Medicine; Humans; Kaplan-Meier Estimate; Male; Metastatic colorectal cancer; Middle Aged; Neoplasm Staging; Prognosis; Proportional Hazards Models; Registries; Subgroups; Survival; Survival Analysis; Survival Rate; Time Factors; CNS metastasis; Survival; Brain metastasis; Metastatic colorectal cancer; Subgroups
• ISSN: 1533-0028; 1938-0674
• DOI: 10.1016/j.clcc.2015.05.009

Micro-Abstract To our knowledge, this is the largest number of patients with colorectal cancer and brain metastasis (BM) analyzed to date (n = 228; 134 male [59%]; 94 female [41%]; median age 63 years). Most primary tumors were staged as T3/4, N+, Grade 2. BM occurred 29.2 months after initial diagnosis. Overall survival from the time of first diagnosis was 35.6 months, from the time of metastatatic disease 16.5 months, and from BM 2.0 months. Solitary BM were found in 13.6%. 80.7% of all BM occurred sequentially.