Patch Closure of Muscular Ventricular Septal Defects With a New Hybrid Therapy in a Pig Model

Patch Closure of Muscular Ventricular Septal Defects With a New Hybrid Therapy in a Pig Model Rainer Kozlik-Feldmann, Nora Lang, Regine Aumann, Anja Lehner, Darius Rassoulian, Ralf Sodian, Christoph Schmitz, Martin Hinterseer, Rabea Hinkel, Eckart Thein, Franz Freudenthal, Nikolay V. Vasylev, Pedro...

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Published inJournal of the American College of Cardiology Vol. 51; no. 16; pp. 1597 - 1603
Main Authors Kozlik-Feldmann, Rainer, MD, Lang, Nora, MD, Aumann, Regine, MD, Lehner, Anja, MS, Rassoulian, Darius, MD, Sodian, Ralf, MD, PhD, Schmitz, Christoph, MD, PhD, Hinterseer, Martin, MD, Hinkel, Rabea, MD, PhD, Thein, Eckart, MD, Freudenthal, Franz, MD, Vasylev, Nikolay V., MD, del Nido, Pedro J., MD, Netz, Heinrich, MD, PhD
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 22.04.2008
Elsevier Science
Elsevier Limited
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Summary:Patch Closure of Muscular Ventricular Septal Defects With a New Hybrid Therapy in a Pig Model Rainer Kozlik-Feldmann, Nora Lang, Regine Aumann, Anja Lehner, Darius Rassoulian, Ralf Sodian, Christoph Schmitz, Martin Hinterseer, Rabea Hinkel, Eckart Thein, Franz Freudenthal, Nikolay V. Vasylev, Pedro J. del Nido, Heinrich Netz We present a new feasible technique of hybrid patch closure for muscular ventricular septal defects (mVSDs) without use of cardiopulmonary bypass in a pig model. The mVSDs were created with a punch instrument under echocardiographic guidance. A patch system composed of a patch with a Nitinol frame was passed across the carotid artery into the left ventricle. An instrument resembling a stapler fixed the patch with Nitinol anchors on the septum via a left ventricular incision under echocardiographic and fluoroscopic guidance. Finally, the Nitinol frame was detached from the patch. Further development of the patch system is necessary to assess applicability in humans.
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ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2007.10.068