Lowered Delta Activity in Post-COVID-19 Patients with Fatigue and Cognitive Impairment

In post-COVID-19 syndrome (PCS), neurocognitive symptoms and fatigue are often associated with alterations in electroencephalographic (EEG) activity. The present study investigates the brain source activity at rest in PCS patients (PCS-pts) perceiving cognitive deficits and fatigue. A total of 18 PC...

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Published inBiomedicines Vol. 11; no. 8; p. 2228
Main Authors Ortelli, Paola, Quercia, Angelica, Cerasa, Antonio, Dezi, Sabrina, Ferrazzoli, Davide, Sebastianelli, Luca, Saltuari, Leopold, Versace, Viviana, Quartarone, Angelo
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.08.2023
MDPI
Subjects
Chronic illnesses
Cognition
Cognitive ability
cognitive impairment
Comparative analysis
COVID-19
EEG
Electroencephalography
eLORETA
Executive function
Fatigue
Hd-EEG
Infections
Memory
Nervous system
Neural networks
Neurons
Neurophysiology
Neuropsychology
Pathophysiology
post-COVID syndrome
Severe acute respiratory syndrome coronavirus 2
Signal processing
Somatotropin
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Summary:In post-COVID-19 syndrome (PCS), neurocognitive symptoms and fatigue are often associated with alterations in electroencephalographic (EEG) activity. The present study investigates the brain source activity at rest in PCS patients (PCS-pts) perceiving cognitive deficits and fatigue. A total of 18 PCS-pts and 18 healthy controls (HCs) were enrolled. A Montreal Cognitive Assessment (MoCA), Perceived Cognitive Difficulties Scale (PDCS) and Fatigue Severity Scale (FSS) were administered for assessing the symptoms’ severity. Brain activity at rest, both with open (OE) and closed eyes (CE), was recorded by high-density EEG (Hd-EEG) and localized by source estimation. Compared to HCs, PCS-pts exhibited worse performance in executive functions, language and memory, and reported higher levels of fatigue. At resting OE state, PCS-pts showed lower delta source activity over brain regions known to be associated with executive processes, and these changes were negatively associated with PDCS scores. Consistent with recent literature data, our findings could indicate a dysfunction in the neuronal networks involved in executive functions in PCS-pts complaining of fatigue and cognitive impairment.
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These authors contributed equally to this work.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines11082228