Effect of orbitofrontal cortex lesions on temporal discounting in rats

• Published in: Behavioural brain research Vol. 245; pp. 22 - 28
• Main Authors: Jo, Suhyun, Kim, Ko-Un, Lee, Daeyeol, Jung, Min Whan
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier B.V 15.05.2013; Elsevier
• Subjects: Analysis of Variance; Animals; Behavioral psychophysiology; Biological and medical sciences; Choice Behavior; Conditioning, Operant - physiology; Data Interpretation, Statistical; Decision making; Delayed reward; Fundamental and applied biological sciences. Psychology; Intertemporal choice; Learning - physiology; Male; Maze Learning - physiology; Models, Neurological; Orbitofrontal cortex; Prefrontal Cortex - anatomy & histology; Prefrontal Cortex - injuries; Prefrontal Cortex - physiology; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Reward; Temporal discounting; Orbitofrontal cortex; Temporal discounting; Decision making; Delayed reward; OFC; BIC; Intertemporal choice; Rat; Rodentia; Central nervous system; Encephalon; Time lag; Vertebrata; Mammalia; Animal; Lesion; Reward
• ISSN: 0166-4328; 1872-7549
• DOI: 10.1016/j.bbr.2013.02.014

► Temporal discounting of the rat was studied using a novel inter-temporal choice task. ► Rat's choices were better explained by hyperbolic than exponential discount functions. ► Two-parameter discount functions were superior to single-parameter discount functions. ► Orbitofrontal cortex lesions did not alter rat's inter-temporal choice behavior. Although choices of both humans and animals are more strongly influenced by immediate than delayed rewards, methodological limitations have made it difficult to estimate the precise form of temporal discounting in animals. In the present study, we sought to characterize temporal discounting in rats and to test the role of the orbitofrontal cortex (OFC) in this process. Rats were trained in a novel intertemporal choice task in which the sequence of delay durations was randomized across trials. The animals tended to choose a small immediate reward more frequently as the delay for a large reward increased, and, consistent with previous findings in other species, their choice behavior was better accounted for by hyperbolic than exponential discount functions. In addition, model comparisons showed that the animal's choice behavior was better accounted for by more complex discount functions with an additional parameter than a hyperbolic discount function. Following bilateral OFC lesions, rats extensively trained in this task showed no significant change in their intertemporal choice behavior. Our results suggest that the rodent OFC may not always play a role in temporal discounting when delays are randomized and/or after extensive training.