Disruption of fetal hormonal programming (prenatal stress) implicates shared risk for sex differences in depression and cardiovascular disease

Highlights • Fetal origins of MDD–CVD comorbidity predict higher risk in women (66). • Prenatal stress explains shared sex differences in mood, ANS, and the vasculature (83). • Developmental steroid hormones, GABA, growth factors and genes are key (70). • Sex-dependent development of paraventricular...

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Bibliographic Details
Published inFrontiers in neuroendocrinology Vol. 35; no. 1; pp. 140 - 158
Main Authors Goldstein, J.M, Handa, R.J, Tobet, S.A
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.01.2014
Subjects
Animals
Cardiovascular disease
Cardiovascular Diseases - metabolism
Cardiovascular Diseases - physiopathology
Depression
Depression - metabolism
Depression - physiopathology
Endocrinology & Metabolism
Female
Fetal Development - physiology
Fetal hormonal programming
Humans
Hypothalamus
Male
MDD–CVD comorbidity
Prenatal stress
Risk
Sex Characteristics
Sex differences
Stress, Physiological
Fetal hormonal programming
MDD–CVD comorbidity
Depression
Cardiovascular disease
Sex differences
Hypothalamus
Prenatal stress
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Summary:Highlights • Fetal origins of MDD–CVD comorbidity predict higher risk in women (66). • Prenatal stress explains shared sex differences in mood, ANS, and the vasculature (83). • Developmental steroid hormones, GABA, growth factors and genes are key (70). • Sex-dependent development of paraventricular nucleus is critical (64). • Developmental timing is essential for understanding sex-dependent effects (73).
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ObjectType-Feature-1
ISSN:0091-3022
1095-6808
DOI:10.1016/j.yfrne.2013.12.001