STUDIES ON AGE DIFFERENCE IN MICE FOR THE ACTIVITY OF DRUG-METABOLIZING ENZYMES OF LIVER MICROSOMES

In previous papers, we reported that the activity of drug-metabolizing enzymes was higher in young female rats than in old female rats and that the duration of hexobarbital anesthesia was shorter in the young females than in the old females (1-3). Moreover, it was observed that the induction of micr...

Full description

Saved in:
Bibliographic Details
Published inJapanese journal of pharmacology Vol. 20; no. 4; pp. 572 - 576
Main Authors KATO, RYUICHI, TAKANAKA, AKIRA, ONODA, KIN-IGHI
Format Journal Article
LanguageEnglish
Published Japan The Japanese Pharmacological Society 01.01.1970
Subjects
Aging
Aminopyrine - metabolism
Anesthesia
Aniline Compounds - metabolism
Animals
Body Weight
Cytochromes - analysis
Electron Transport
Hexobarbital - metabolism
In Vitro Techniques
Mice
Microsomes, Liver - enzymology
Nitrobenzenes - metabolism
Oxidoreductases - metabolism
Paralysis - chemically induced
Strychnine - metabolism
Strychnine - toxicity
Zoxazolamine - metabolism
Online AccessGet full text

Cover

More Information
Summary:In previous papers, we reported that the activity of drug-metabolizing enzymes was higher in young female rats than in old female rats and that the duration of hexobarbital anesthesia was shorter in the young females than in the old females (1-3). Moreover, it was observed that the induction of microsomal drug-metabolizing enzymes by phenobarbital was more effective in young rats than in old rats (4, 5). In the present communication, we wish to report the evidence that, in contrast to the results obtained with rats, clear age difference was not observed in the activity of drug-metabolizing enzymes in mice and there was no clear age difference in the induction of drug-metabolizing enzymes by phenobarbital.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.20.572