Role of Fork-Head Box Genes in Breast Cancer: From Drug Resistance to Therapeutic Targets

• Published in: Biomedicines Vol. 11; no. 8; p. 2159
• Main Authors: Sadaf, Hazazi, Ali, Alkhalil, Samia S, Alsaiari, Ahad Amer, Gharib, Amal F, Alhuthali, Hayaa M, Rana, Shanika, Aloliqi, Abdulaziz A, Eisa, Alaa Abdulaziz, Hasan, Mohammad Raghibul, Dev, Kapil
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.08.2023; MDPI
• Subjects: Angiogenesis; Breast cancer; Cancer; Cell cycle; Cell division; Cell growth; Development and progression; DNA damage; Drug resistance; Drug therapy; Epidermal growth factor; Estrogens; forkhead genes; Forkhead protein; forkhead proteins; FOXA; FOXC; FOXM1; FOXO; Gene expression; Genes; Genetic aspects; Health aspects; Medical prognosis; Metabolism; Metastasis; miRNA; Physiology; Prostate cancer; Proteins; Public health; Review; Stem cells; Therapeutic targets; Transcription factors; Transplantation; Tumors; Verteporfin; Saudi Arabia
• ISSN: 2227-9059; 2227-9059
• DOI: 10.3390/biomedicines11082159

Breast cancer has been acknowledged as one of the most notorious cancers, responsible for millions of deaths around the globe. Understanding the various factors, genetic mutations, comprehensive pathways, etc., that are involved in the development of breast cancer and how these affect the development of the disease is very important for improving and revitalizing the treatment of this global health issue. The forkhead-box gene family, comprising 19 subfamilies, is known to have a significant impact on the growth and progression of this cancer. The article looks into the various forkhead genes and how they play a role in different types of cancer. It also covers their impact on cancer drug resistance, interaction with microRNAs, explores their potential as targets for drug therapies, and their association with stem cells.