The Biology of the Nuclear Envelope and Its Implications in Cancer Biology

The formation of the nuclear envelope and the subsequent compartmentalization of the genome is a defining feature of eukaryotes. Traditionally, the nuclear envelope was purely viewed as a physical barrier to preserve genetic material in eukaryotic cells. However, in the last few decades, it has been...

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Bibliographic Details
Published inInternational journal of molecular sciences Vol. 20; no. 10; p. 2586
Main Authors Alvarado Kristensson, Maria, Rossello Castillo, Catalina Ana
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 27.05.2019
MDPI
Subjects
Aging
Apoptosis
Architecture
Basic Medicine
Biology
Cancer
Cell adhesion & migration
Cell cycle
Cell division
Chromatin
Deoxyribonucleic acid
diagnosis
DNA
DNA repair
Endurance
envelope
Enzymatic activity
Gene expression
Gene regulation
genome
Kinases
Lamins
Mammals
Medical and Health Sciences
Medical Genetics
Medicin och hälsovetenskap
Medicinsk genetik
Medicinska och farmaceutiska grundvetenskaper
Membranes
metastasis
Mitosis
Nucleoporins
nucleus
Oxidative metabolism
Proteins
Review
signaling
Tumorigenesis
Tumors
γ-tubulin
genome
envelope
γ-tubulin
signaling
cell cycle
metastasis
diagnosis
nucleus
cancer
mitosis
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Summary:The formation of the nuclear envelope and the subsequent compartmentalization of the genome is a defining feature of eukaryotes. Traditionally, the nuclear envelope was purely viewed as a physical barrier to preserve genetic material in eukaryotic cells. However, in the last few decades, it has been revealed to be a critical cellular component in controlling gene expression and has been implicated in several human diseases. In cancer, the relevance of the cell nucleus was first reported in the mid-1800s when an altered nuclear morphology was observed in tumor cells. This review aims to give a current and comprehensive view of the role of the nuclear envelope on cancer first by recapitulating the changes of the nuclear envelope during cell division, second, by reviewing the role of the nuclear envelope in cell cycle regulation, signaling, and the regulation of the genome, and finally, by addressing the nuclear envelope link to cell migration and metastasis and its use in cancer prognosis.
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ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms20102586