ABO blood group system and gastric cancer: a case-control study and meta-analysis

• Published in: International journal of molecular sciences Vol. 13; no. 10; pp. 13308 - 13321
• Main Authors: Wang, Zhiwei, Liu, Lei, Ji, Jun, Zhang, Jianian, Yan, Min, Zhang, Jun, Liu, Bingya, Zhu, Zhenggang, Yu, Yingyan
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 17.10.2012; Molecular Diversity Preservation International (MDPI)
• Subjects: ABO blood group; ABO Blood-Group System; Asian cohort; Blood & organ donations; Blood groups; Case-Control Studies; Cohort Studies; Gastric cancer; Helicobacter Infections - pathology; Helicobacter pylori; Humans; Infections; Meta-analysis; Odds Ratio; Risk Factors; Scandals; Stomach Neoplasms - metabolism; Stomach Neoplasms - pathology
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms131013308

This study focuses on the association between the ABO blood group system and the risk of gastric cancer or Helicobacter pylori infection. The data for the ABO blood group was collected from 1045 cases of gastric cancer, whereby the patient underwent a gastrectomy in Ruijin Hospital, Shanghai. The information on the ABO blood group from 53,026 healthy blood donors was enrolled as control. We searched the Pubmed database on the relationship between ABO blood groups and gastric cancer risk for meta-analysis. In our case-control study, the risk of gastric cancer in blood group A was significantly higher than that in non-A groups (O, B and AB) (odd ratio, OR1.34; 95% confidential interval, CI 1.25-1.44). Compared with non-O groups (A, B and AB), individuals with blood group O demonstrated a reduced risk of gastric cancer (OR = 0.80; 95% CI 0.72-0.88). The proportion of H. pylori infection in blood group A individuals was significantly higher than that in non-A blood groups (OR = 1.42; 95% CI 1.05-1.93). We further combined our data with the published data of others, and crossreferenced the risk of gastric cancer with the blood type, finding consistent evidence that gastric cancer risk in the blood A group was higher than that in the non-A groups (OR = 1.11; 95% CI 1.07-1.15), and that blood type O individuals were consistently shown gastric cancer risk reduction (OR = 0.91; 95% CI 0.89-0.94). Our study concluded that there was a slightly increased risk of gastric cancer in blood group A individuals, and people with blood type A are more prone to be infected by H. pylori than other ABO blood type individuals, whereas, a slightly decreased risk of gastric cancer was identified in blood type O individuals.