Know thy neighbor: stromal cells can contribute oncogenic signals

Although the stroma within carcinogenic lesions is known to be supportive and responsive to tumors, new data increasingly show that the stroma also has a more active, oncogenic role in tumorigenesis. Stromal cells and their products can transform adjacent tissues in the absence of pre-existing tumor...

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Bibliographic Details
Published inCurrent Opinion in Genetics & Development Vol. 11; no. 1; pp. 54 - 59
Main Authors Tlsty, Thea D, Hein, Patrick W
Format Book Review Journal Article
LanguageEnglish
Published Legacy CDMS Elsevier Ltd 01.02.2001
Subjects
Carcinogens - toxicity
Cell Transformation, Neoplastic
Cell Transformation, Viral
Extracellular Matrix - metabolism
Humans
Life Sciences (General)
Matrix Metalloproteinases - metabolism
MMPs
Neoplasms - etiology
Neoplasms - pathology
Oncogenes
Oncogenesis
Phenotype
Signal Transduction
Stroma
Stromal Cells - metabolism
Stromal Cells - pathology
Stromal Cells - physiology
Stroma
Oncogenesis
MMPs
Non-Nasa Center
Nasa Discipline Radiation Health
Review
Review, Tutorial
NASA Discipline Radiation Health
Non-NASA Center
Online AccessGet full text

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Summary:Although the stroma within carcinogenic lesions is known to be supportive and responsive to tumors, new data increasingly show that the stroma also has a more active, oncogenic role in tumorigenesis. Stromal cells and their products can transform adjacent tissues in the absence of pre-existing tumor cells by inciting phenotypic and genomic changes in the epithelial cells. The oncogenic action of distinctive stromal components has been demonstrated through a variety of approaches, which provide clues about the cellular pathways involved.
Bibliography:CDMS
Legacy CDMS
ISSN:0959-437X
1879-0380
DOI:10.1016/S0959-437X(00)00156-8