Osteoblast Behavior on Hierarchical Micro-/Nano-Structured Titanium Surface

• Published in: Journal of bionics engineering Vol. 8; no. 3; pp. 234 - 241
• Main Authors: Meng, Weiyan, Zhou, Yanmin, Zhang, Yanjing, Cai, Qing, Yang, Liming, Zhao, Jinghui, Li, Chunyan
• Format: Journal Article
• Language: English
• Published: Singapore Elsevier Ltd 01.09.2011; Springer Singapore
• Subjects: Artificial Intelligence; Biochemical Engineering; Bioinformatics; Biomaterials; Biomedical Engineering and Bioengineering; Biomedical Engineering/Biotechnology; dental implant; electrolytic etching; Engineering; hierarchical micro-/nano-structure; osteoblast; SLA; surface treatment; 成骨细胞; 早期阶段; 电解腐蚀; 细胞培养; 细胞行为; 表面地形; 钛表面; surface treatment; osteoblast; electrolytic etching; dental implant; hierarchical micro-/nano-structure
• ISSN: 1672-6529; 2543-2141
• DOI: 10.1016/S1672-6529(11)60031-0

In the present work, osteoblast behavior on a hierarchical micro-/nano-structured titanium surface was investigated. A hierarchical hybrid micro-/nano-structured titanium surface topography was produced via Electrolytic Etching (EE). MG-63 cells were cultured on disks for 2 h to 7 days. The osteoblast response to the hierarchical hybrid micro-/nano-structured titanium surface was evaluated through the osteoblast cell morphology, attachment and proliferation. For comparison, MG-63 cells were also cultured on Sandblasted and Acid-etched (SLA) as well as Machined (M) surfaces respectively. The results show significant differences in the adhesion rates and proliferation levels of MG-63 cells on EE, SLA, and M surfaces. Both adhesion rate and proliferation level on EE surface are higher than those on SLA and M surfaces. Therefore, we may expect that, comparing with SLA and M surfaces, bone growth on EE surface could be accelerated and bone formation could be promoted at an early stage, which could be applied in the clinical practices for immediate and early-stage loadings.