A Comprehensive Review on the Manipulation of the Sphingolipid Pathway by Pathogenic Bacteria

Bacterial pathogens have developed many different strategies to hijack host cell responses to promote their own survival. The manipulation of lipid biogenesis and cell membrane stability is emerging as a key player in bacterial host cell control. Indeed, many bacterial pathogens such as , or are abl...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in cell and developmental biology Vol. 7; p. 168
Main Authors Rolando, Monica, Buchrieser, Carmen
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers media 21.08.2019
Frontiers Media S.A
SeriesSphingolipids in Infection Control
Subjects
Cell and Developmental Biology
Cellular Biology
host-pathogen interactions
Legionella
Life Sciences
Microbiology and Parasitology
Mycobacteria
Pseudomonas
sphingolipids
host-pathogen interactions
Legionella
Pseudomonas
sphingolipids
Mycobacteria
Online AccessGet full text

Cover

More Information
Summary:Bacterial pathogens have developed many different strategies to hijack host cell responses to promote their own survival. The manipulation of lipid biogenesis and cell membrane stability is emerging as a key player in bacterial host cell control. Indeed, many bacterial pathogens such as , or are able to manipulate and use host sphingolipids during multiple steps of the infectious process. Sphingolipids have long been considered only as structural components of cell membranes, however, it is now well known that they are also intracellular and intercellular signaling molecules that play important roles in many eukaryotic cell functions as well as in orchestrating immune responses. Furthermore, they are important to eliminate invading pathogens and play a crucial role in infectious diseases. In this review, we focus on the different strategies employed by pathogenic bacteria to hijack the sphingolipid balance in the host cell to promote cellular colonization.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
PMCID: PMC6712060
Reviewed by: Astrid M. Westendorf, University of Duisburg-Essen, Germany; Martin Fraunholz, Julius Maximilian University of Würzburg, Germany
This article was submitted to Membrane Physiology and Membrane Biophysics, a section of the journal Frontiers in Cell and Developmental Biology
Edited by: Sibylle Schneider-Schaulies, Julius Maximilian University of Würzburg, Germany
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2019.00168