Role of Sug1, a 19S proteasome ATPase, in the transcription of MHC I and the atypical MHC II molecules, HLA-DM and HLA-DO

• Published in: Immunology letters Vol. 147; no. 1; pp. 67 - 74
• Main Authors: Inostroza-Nieves, Yaritza, Venkatraman, Prasanna, Zavala-Ruiz, Zarixia
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2012
• Subjects: 19S ATPase; Acetylation - drug effects; Adaptor Proteins, Signal Transducing - genetics; Adaptor Proteins, Signal Transducing - metabolism; Allergy and Immunology; ATPases Associated with Diverse Cellular Activities; Cell Line; CREB-Binding Protein - metabolism; Gene Expression Regulation - drug effects; Histocompatibility Antigens Class I - genetics; Histones - metabolism; HLA-D Antigens - genetics; HLA-DM; HLA-DO; Humans; Interferon-gamma - pharmacology; LIM Domain Proteins - genetics; LIM Domain Proteins - metabolism; MHC class I; Nuclear Proteins - metabolism; Promoter Regions, Genetic; Proteasome Endopeptidase Complex; RNA Interference; Sug1; Trans-Activators - metabolism; Transcription Factors - genetics; Transcription Factors - metabolism; Transcription, Genetic - drug effects; Transcriptional regulation; MHC class I; HLA-DO; HLA-DM; Sug1; Transcriptional regulation; 19S ATPase
• ISSN: 0165-2478; 1879-0542
• DOI: 10.1016/j.imlet.2012.06.005

Highlights ► Sug1 is required for optimal gene expression of MHC I, and the atypical MHC II proteins HLA-DM and HLA-DO. ► Sug1 binds directly and specifically to the HLA promoters. ► Histone H3 acetylation at the HLA promoters decreases in the absence of Sug1. ► Sug1 is essential for CBP and CIITA recruitment to the MHC promoters.