The pulmonary histopathologic manifestations of the anti-PL7/antithreonyl transfer RNA synthetase syndrome

Summary The pulmonary histopathologic manifestations of the antisynthetase syndromes is poorly understood and reported. Eight cases of interstitial lung disease related to the presence of antitheonyl (PL7) transfer RNA synthetase autoantibodies along with a review of biopsy changes reported in the E...

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Bibliographic Details
Published inHuman pathology Vol. 45; no. 6; pp. 1199 - 1204
Main Authors Yousem, Samuel A., MD, Schneider, Frank, MD, Bi, David, Oddis, Chester V., MD, Gibson, Kevin, MD, Aggarwal, Rohit, MD, MS
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.06.2014
Elsevier Limited
Subjects
Adult
Aged
Aged, 80 and over
Amino Acyl-tRNA Synthetases - immunology
Antisynthetase syndrome
Arthritis
Autoimmune
Biopsy
Colleges & universities
Dysphagia
Female
Histopathology
Humans
Lung
Lung diseases
Lung Diseases, Interstitial - etiology
Lung Diseases, Interstitial - pathology
Male
Medical records
Middle Aged
Myositis - complications
Myositis - pathology
Pathology
Patients
PL7
Raynaud disease
Transfer RNA
Transplants & implants
Antisynthetase syndrome
PL7
Autoimmune
Lung
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Summary:Summary The pulmonary histopathologic manifestations of the antisynthetase syndromes is poorly understood and reported. Eight cases of interstitial lung disease related to the presence of antitheonyl (PL7) transfer RNA synthetase autoantibodies along with a review of biopsy changes reported in the English literature are described. Most patients presented with dyspnea and cough, with myositis, skin changes including “mechanic's hands,” and Raynaud phenomenon. Biopsy patterns of injury included usual interstitial pneumonia (n = 4), organizing pneumonia (n = 2), nonspecific interstitial pneumonia, and lymphoid interstitial pneumonia (n = 1 each), which, in a minority of instances, contrasted with predictions by thoracic radiologists based on high-resolution computed tomographic scans. This study emphasizes the integrated clinical, radiologic, and pathologic approach to interstitial lung disease, especially in connective tissue disorders, and points out the occurrence of usual interstitial pneumonia and organizing pneumonia in this patient group where nonspecific interstitial pneumonia has been the dominant pattern of clinical interest.
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ISSN:0046-8177
1532-8392
DOI:10.1016/j.humpath.2014.01.018