Combined antibacterial effects of tissue-tolerable plasma and a modern conventional liquid antiseptic on chronic wound treatment

• Published in: Journal of biophotonics Vol. 8; no. 5; pp. 382 - 391
• Main Authors: Klebes, Martin, Ulrich, Christin, Kluschke, Franziska, Patzelt, Alexa, Vandersee, Staffan, Richter, Heike, Bob, Adrienne, von Hutten, Johanna, Krediet, Jorien T., Kramer, Axel, Lademann, Jürgen, Lange-Asschenfeld, Bernhard
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 01.05.2015; WILEY‐VCH Verlag; Wiley Subscription Services, Inc
• Subjects: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents - adverse effects; Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - therapeutic use; Anti-Infective Agents, Local - adverse effects; Anti-Infective Agents, Local - pharmacology; Anti-Infective Agents, Local - therapeutic use; Antiinfectives and antibacterials; antiseptic efficacy; Antiseptics; Bacteria; chronic wounds; Counting; Drug Interactions; Effectiveness; Exudates and Transudates - drug effects; Female; Humans; Leg Ulcer - drug therapy; Leg Ulcer - microbiology; Leg Ulcer - pathology; Leg Ulcer - physiopathology; Liquids; Male; Middle Aged; octenidine dihydrochloride (ODC); Pain - chemically induced; Plasma Gases - adverse effects; Plasma Gases - pharmacology; Plasma Gases - therapeutic use; Strain; tissue tolerable plasma (TTP); Ulcers; wound disinfection; Wound Healing - drug effects; antiseptic efficacy; octenidine dihydrochloride (ODC); tissue tolerable plasma (TTP); wound disinfection; chronic wounds
• ISSN: 1864-063X; 1864-0648
• DOI: 10.1002/jbio.201400007

Potential antimicrobial effects of sequential applications of tissue‐tolerable plasma (TTP) and the conventional liquid antiseptic octenidine dihydrochloride (ODC) were investigated. 34 patients with chronic leg ulcers were treated with TTP, ODC or a combination of both. The bacterial colonization was measured semi‐quantitatively before and immediately after treatment and changes in the microbial strains' compositions before and after antiseptic treatments were analyzed. All antiseptic procedures reduced the bacterial counts significantly. The sequential application of TTP and ODC displayed the highest antimicrobial efficacy. Me combined use of TTP and conventional antiseptics might represent the most efficient strategy for antiseptic treatment of chronic wounds. (© 2014 WILEY‐VCH Verlag GmbH &Co. KGaA, Weinheim) Potential antimicrobial effects of sequential applications of tissue‐tolerable plasma (TTP) and the conventional liquid antiseptic octenidine dihydrochloride (ODC) were investigated. Patients with chronic leg ulcers were treated with TTP, ODC or a combination of both. The bacterial colonization was measured semi‐quantitatively before and immediately after treatment and changes in the microbial strains’ compositions before and after antiseptic treatments were analyzed. All antiseptic procedures reduced the bacterial counts significantly. The sequential application of TTP and ODC displayed the highest antimicrobial efficacy.