Identification of monocyte chemoattractant protein‐1 in senile plaques and reactive microglia of Alzheimer's disease

• Published in: Psychiatry and clinical neurosciences Vol. 51; no. 3; pp. 135 - 138
• Main Authors: ISHIZUKA, KOKO, KIMURA, TAKEMI, IGATA‐YI, RURIKO, KATSURAGI, SHOICHI, TAKAMATSU, JUNICHI, MIYAKAWA, TAIHEI
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.06.1997; Blackwell Publishing
• Subjects: Aged; Alzheimer Disease - immunology; Alzheimer Disease - physiopathology; Alzheimer's disease; Biological and medical sciences; Brain Chemistry; Chemokine CCL2 - isolation & purification; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Humans; Immunohistochemistry; Inflammation; Medical sciences; Microglia - immunology; microglias; Middle Aged; monocyte chemoattractant protein‐1; Neurofibrillary Tangles - immunology; Neurology; senile plaques; Human; Immunohistochemistry; Nervous system diseases; Senile plate; Monocyte; Pathophysiology; Alzheimer disease; Exploration; Cerebral disorder; Microglia; Pathology; Central nervous system disease; Degenerative disease; Brain (vertebrata)
• ISSN: 1323-1316; 1440-1819
• DOI: 10.1111/j.1440-1819.1997.tb02375.x

It has been shown that human monocytes express monocyte chemoattractant protein‐1 (MCP‐1), an inflammatry factor, in response to non‐fibrillar β‐amyloid protein. Reactive microglia and inflammatory factors were reported to be present in β‐amyloid deposits (senile plaques) in Alzheimer's disease, suggesting the presence of MCP‐1 in senile plaques. To address this issue, we examined MCP‐1‐immunoreactivity in senile plaques using a mouse monoclonal anti‐MCP‐1 antibody. Monocyte chemoattractant protein‐1 was found immunohistochemically in mature senile plaques and reactive microglia but not in immature senile plaques of brain tissues from five patients with Alzheimer's disease. These findings suggest that MCP‐1‐related inflammatory events induced by reactive microglia contribute to the maturation of senile plaques.