pH-Switchable Ampholytic Supramolecular Copolymers

β‐sheet‐encoded anionic and cationic dendritic peptide amphiphiles form supramolecular copolymers when self‐assembled in a 1:1 feed ratio of the monomers. These ampholytic materials have been designed for on‐off polymerization in response to pH triggers. The cooperative supramolecular self‐assembly...

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Bibliographic Details
Published inAngewandte Chemie International Edition Vol. 52; no. 38; pp. 10097 - 10101
Main Authors Frisch, Hendrik, Unsleber, Jan Patrick, Lüdeker, David, Peterlechner, Martin, Brunklaus, Gunther, Waller, Mark, Besenius, Pol
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 16.09.2013
WILEY‐VCH Verlag
Wiley Subscription Services, Inc
EditionInternational ed. in English
Subjects
Cationic
cooperativity
copolymerization
Copolymers
Hydrogen-Ion Concentration
Molecular Structure
Monomers
Peptides
pH switch
Polymerization
Polymers - chemical synthesis
Polymers - chemistry
Self assembly
stimuli-responsive behavior
copolymerization
self-assembly
cooperativity
pH switch
stimuli-responsive behavior
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Summary:β‐sheet‐encoded anionic and cationic dendritic peptide amphiphiles form supramolecular copolymers when self‐assembled in a 1:1 feed ratio of the monomers. These ampholytic materials have been designed for on‐off polymerization in response to pH triggers. The cooperative supramolecular self‐assembly process is switched on at a physiologically relevant pH value and can be switched off by increasing or decreasing the pH value.
Bibliography:We thank Prof. Dr. Bart Jan Ravoo for critical reading of the manuscript, and acknowledge funding from the "Fonds der Chemischen Industrie" for a doctoral Fellowship (H.F.) and a Liebig Fellowship (P.B.).
ArticleID:ANIE201303810
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ark:/67375/WNG-28RS20L8-Z
We thank Prof. Dr. Bart Jan Ravoo for critical reading of the manuscript, and acknowledge funding from the “Fonds der Chemischen Industrie” for a doctoral Fellowship (H.F.) and a Liebig Fellowship (P.B.).
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201303810