Antifungal Effect of Polymethyl Methacrylate Resin Base with Embedded Au Nanoparticles

• Published in: Nanomaterials (Basel, Switzerland) Vol. 13; no. 14; p. 2128
• Main Authors: Marić, Ivan, Zore, Anamarija, Rojko, Franc, Škapin, Andrijana Sever, Štukelj, Roman, Učakar, Aleksander, Vidrih, Rajko, Veselinović, Valentina, Gotić, Marijan, Bohinc, Klemen
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.07.2023; MDPI
• Subjects: Acrylic resins; Adhesion; Aesthetics; Analysis; Antifungal activity; Antifungal agents; Antimicrobial agents; Biocompatibility; Biofilms; C. albicans; Candida albicans; Composite materials; composites; Dentistry; Drug resistance; E coli; Extracellular matrix; Extracellular vesicles; fungal adhesion; Fungicides; Gold; Infections; Mechanical properties; Microorganisms; Nanoparticles; Nanotechnology; Oral hygiene; Polymethyl methacrylate; polymethyl methacrylate resin; Polymethylmethacrylate; Properties; Prostheses; surface properties; Teeth; Tensile strength; Slovenia; composites; Au; C. albicans; fungal adhesion; surface properties; polymethyl methacrylate resin
• ISSN: 2079-4991; 2079-4991
• DOI: 10.3390/nano13142128

Full and partial restorations in dentistry must replicate the characteristics of the patient's natural teeth. Materials must have good mechanical properties and be non-toxic and biocompatible. Microbes, which can form biofilms, are constantly in contact with restorations. In this study, we investigate how well adheres to a polymethyl methacrylate (PMMA) resin base with gold (Au) nanoparticles. We synthesized Au nanoparticles and characterized them. The average size of Au nanoparticles embedded in PMMA was 11 nm. The color difference ΔE between PMMA and PMMA/Au composites was 2.7 and was still esthetically acceptable to patients. PMMA/Au surfaces are smoother and more hydrophilic than pure PMMA surfaces, and the isoelectric point of both types of surfaces was 4.3. Above the isoelectric point, PMMA/Au surfaces are more negatively charged than PMMA surfaces. The added Au nanoparticles decreased the tensile strength, while the hardness did not change significantly. Adhesion measurements showed that PMMA surfaces modified with Au nanoparticles reduced the extent of microbial adhesion of .