Sacroiliitis in Systemic Lupus Erythematosus Revisited

• Published in: Archives of rheumatology Vol. 35; no. 2; pp. 254 - 258
• Main Authors: Yilmaz, Neslihan, Yazici, Ayten, Özulu TÜrkmen, Banu, Karalok, Işık, Yavuz, Şule
• Format: Journal Article
• Language: English
• Published: Turkey Turkish League Against Rheumatism 01.06.2020; Prof Sebnem Ataman, President Turkish League Against Rheumatism
• Subjects: Age; Antigens; Arthritis; B cells; Back pain; Backache; Deoxyribonucleic acid; DNA; Edema; Family medical history; Histocompatibility antigens; HLA histocompatibility antigens; Lupus; Magnetic resonance imaging; Medical research; Medicine, Experimental; Original; Patients; Population; Questionnaires; Rheumatology; Sacroiliitis; Somatotropin; Statistical analysis; Systemic lupus erythematosus; lupus; Inflammatory back pain; sacroiliitis
• ISSN: 2148-5046; 1309-0291; 2618-6500; 1309-0283
• DOI: 10.46497/ArchRheumatol.2020.7514

This study aims to investigate the prevalence of inflammatory back pain (IBP) and sacroiliitis in a systemic lupus erythematosus (SLE) population as well as the association between IBP and the frequency of human leukocyte antigen B27 (HLA-B27). The study included 281 SLE patients (16 males, 265 females; mean age 39.9±11.9 years; range, 20 to 69 years) and 100 healthy controls (HCs) (2 males, 98 females; mean age 41.2±10.1 years; range, 19 to 64 years). Participants were administered a five-item Assessment of SpondyloArthritis international Society-IBP questionnaire. Patients and controls with IBP underwent detailed clinical and laboratory examinations to detect sacroiliitis. Radiographic evaluations were performed by a blinded rheumatologist and radiologist. Interobserver reliability was assessed with Cohen's kappa test. According to the questionnaire, IBP was present in 46 SLE patients (46/281; 16.3%) whereas none of the HC had IBP (p<0.001). In radiological assessment, 22 SLE patients (7.8%) had sacroiliitis detected by conventional X-ray and/or magnetic resonance imaging. Only one SLE patient with sacroiliitis had HLA-B27. Our study showed that IBP is increased in SLE patients and IBP in SLE is not associated with HLA-B27.