Differences in the treatment needs of patients with dementia with Lewy bodies and their caregivers and differences in their physicians' awareness of those treatment needs according to the clinical department visited by the patients: a subanalysis of an observational survey study

• Published in: Alzheimer's research & therapy Vol. 16; no. 1; pp. 59 - 12
• Main Authors: Ikeda, Manabu, Toya, Shunji, Manabe, Yuta, Yamakage, Hajime, Hashimoto, Mamoru
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 14.03.2024; BioMed Central; BMC
• Subjects: Aged; Alzheimer's disease; Antipsychotics; Attending physicians; Care and treatment; Caregivers; Caregivers - psychology; Chi-square test; Cholinesterase Inhibitors - therapeutic use; Clinical department; Cognitive ability; Consent; Cross-Sectional Studies; Dementia; Dementia with Lewy bodies; Departments; Eating behavior; Ethics; Humans; Internal medicine; Lewy body disease; Lewy Body Disease - diagnosis; Lewy Body Disease - drug therapy; Mentally ill; Multicenter Studies as Topic; Neurosurgery; Observational Studies as Topic; Observational study; Patients; Physician and patient; Physicians; Psychological aspects; Questionnaires; Statistical analysis; Surveys; Japan; Caregivers; Observational study; Survey; Treatment needs; Clinical department; Subanalysis; Attending physicians; Patients; Dementia with Lewy bodies
• ISSN: 1758-9193; 1758-9193
• DOI: 10.1186/s13195-024-01419-6

We investigated whether the treatment needs of patients with dementia with Lewy bodies (DLB) and their caregivers, along with their attending physicians' perception of those treatment needs, differ according to the clinical department visited by the patients. This was a subanalysis of a multicenter, cross-sectional, observational survey study. Data from the main study were classified according to the clinical department visited by the patient: psychiatric group (P-group), geriatric internal medicine group (G-group), and neurology group (N-group). The treatment needs of patients and caregivers were defined as "the symptom that causes them the most distress", and the frequency of each answer was tabulated. This subanalysis included 134, 65, and 49 patient-caregiver pairs in the P-, G-, and N-groups, respectively. Statistically significant differences in patient background characteristics such as patient age; initial symptom domains; use of cholinesterase inhibitors, levodopa, antipsychotics, and Yokukansan; and total scores of the Mini-Mental State Examination, Neuropsychiatric Inventory-12, and Movement Disorder Society-Unified Parkinson's Disease Rating Scale Parts II and III were shown among the three subgroups. While there were no differences in patients' treatment needs among the subgroups, residual analysis showed that in the N-group, parkinsonism was more of a problem than other symptom domains (p = 0.001). There were significant differences in caregivers' treatment needs among the three subgroups (p < 0.001). The patient-physician concordance rates for the symptom domains that caused patients the most distress were: P-group, 42.9% (kappa coefficient [κ] = 0.264); G-group, 33.3% (κ = 0.135), and N-group, 67.6% (κ = 0.484). The caregiver-physician concordance rates for the symptom domains that caused the caregivers the most distress were: P-group, 54.8% (κ = 0.351), G-group, 50.0% (κ = 0.244), and N-group, 47.4% (κ = 0.170). This subanalysis revealed differences in the treatment needs of patients with DLB and their caregivers according to the clinical department they attended. There might be a lack of awareness of those treatment needs by the attending physicians, regardless of their specialty. UMIN Clinical Trials Registry UMIN000041844.