Advances in Integrated Multi-omics Analysis for Drug-Target Identification

As an essential component of modern drug discovery, the role of drug-target identification is growing increasingly prominent. Additionally, single-omics technologies have been widely utilized in the process of discovering drug targets. However, it is difficult for any single-omics level to clearly e...

Full description

Saved in:
Bibliographic Details
Published inBiomolecules (Basel, Switzerland) Vol. 14; no. 6; p. 692
Main Authors Du, Peiling, Fan, Rui, Zhang, Nana, Wu, Chenyuan, Zhang, Yingqian
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.06.2024
MDPI
Subjects
Analysis
Biological analysis
Computational Biology - methods
CRISPR
Disease
Drug development
Drug discovery
Drug Discovery - methods
drug target
Drugs
Gene expression
Genetic engineering
Genomes
Genomics
Genomics - methods
Humans
Identification
Localization
Metabolism
Metabolites
Metabolomics - methods
multi-omics
Multiomics
Mutation
Organisms
Phenotypes
Physiology
Proteins
proteogenomics
Proteomics
Proteomics - methods
Review
single-cell multi-omics
spatial multi-omics
Technology
Therapeutic targets
multi-omics
proteogenomics
drug target
spatial multi-omics
single-cell multi-omics
Online AccessGet full text

Cover

More Information
Summary:As an essential component of modern drug discovery, the role of drug-target identification is growing increasingly prominent. Additionally, single-omics technologies have been widely utilized in the process of discovering drug targets. However, it is difficult for any single-omics level to clearly expound the causal connection between drugs and how they give rise to the emergence of complex phenotypes. With the progress of large-scale sequencing and the development of high-throughput technologies, the tendency in drug-target identification has shifted towards integrated multi-omics techniques, gradually replacing traditional single-omics techniques. Herein, this review centers on the recent advancements in the domain of integrated multi-omics techniques for target identification, highlights the common multi-omics analysis strategies, briefly summarizes the selection of multi-omics analysis tools, and explores the challenges of existing multi-omics analyses, as well as the applications of multi-omics technology in drug-target identification.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ISSN:2218-273X
2218-273X
DOI:10.3390/biom14060692