Ribosome-Directed Therapies in Cancer

The human ribosomes are the cellular machines that participate in protein synthesis, which is deeply affected during cancer transformation by different oncoproteins and is shown to provide cancer cell proliferation and therefore biomass. Cancer diseases are associated with an increase in ribosome bi...

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Published inBiomedicines Vol. 10; no. 9; p. 2088
Main Authors Temaj, Gazmend, Chichiarelli, Silvia, Eufemi, Margherita, Altieri, Fabio, Hadziselimovic, Rifat, Farooqi, Ammad Ahmad, Yaylim, Ilhan, Saso, Luciano
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 26.08.2022
MDPI
Subjects
Binding sites
Biosynthesis
Cancer
Care and treatment
Cell division
Cell proliferation
DNA damage
Evolution
Mutation
Protein biosynthesis
Protein synthesis
Proteins
Review
Ribosomal DNA
Ribosomal proteins
ribosome
Ribosomes
RNA polymerase
rRNA and tRNA inhibition
Signal transduction
target drugs
United States
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Summary:The human ribosomes are the cellular machines that participate in protein synthesis, which is deeply affected during cancer transformation by different oncoproteins and is shown to provide cancer cell proliferation and therefore biomass. Cancer diseases are associated with an increase in ribosome biogenesis and mutation of ribosomal proteins. The ribosome represents an attractive anti-cancer therapy target and several strategies are used to identify specific drugs. Here we review the role of different drugs that may decrease ribosome biogenesis and cancer cell proliferation.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines10092088