The Role of S100A6 in Human Diseases: Molecular Mechanisms and Therapeutic Potential

S100A6, also known as calcyclin, is a low-molecular-weight Ca -binding protein from the S100 family that contains two EF-hands. S100A6 is expressed in a variety of mammalian cells and tissues. It is also expressed in lung, colorectal, pancreatic, and liver cancers, as well as other cancers such as m...

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Published inBiomolecules (Basel, Switzerland) Vol. 13; no. 7; p. 1139
Main Authors Yang, Fengguang, Ma, Jinglin, Zhu, Daxue, Wang, Zhaoheng, Li, Yanhu, He, Xuegang, Zhang, Guangzhi, Kang, Xuewen
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.07.2023
MDPI
Subjects
Alzheimer's disease
Arthritis
Binding proteins
Biomarkers
Bone cancer
Calcium-binding protein
Cardiovascular diseases
Cardiovascular system
Care and treatment
Cell cycle
Cell differentiation
Cell proliferation
China
Colorectal cancer
Cytoskeleton
Diseases
Endometriosis
Gastric cancer
Health aspects
Homeopathy
Leukemia
Liver cancer
Lymphatic system
Mammalian cells
Materia medica and therapeutics
Medical prognosis
Medical research
Medicine, Experimental
Melanoma
Metastasis
Molecular modelling
myocardial infarction
Nervous system
Nervous system diseases
Osteoarthritis
Pancreatic cancer
Pathogenesis
Physiological aspects
Proteins
Review
S100A6
S100A6 protein
Therapeutic targets
Therapeutics
Thyroid gland
tumor
Tumors
China
S100A6
endometriosis
leukemia
Alzheimer’s disease
tumor
myocardial infarction
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Summary:S100A6, also known as calcyclin, is a low-molecular-weight Ca -binding protein from the S100 family that contains two EF-hands. S100A6 is expressed in a variety of mammalian cells and tissues. It is also expressed in lung, colorectal, pancreatic, and liver cancers, as well as other cancers such as melanoma. S100A6 has many molecular functions related to cell proliferation, the cell cycle, cell differentiation, and the cytoskeleton. It is not only involved in tumor invasion, proliferation, and migration, but also the pathogenesis of other non-neoplastic diseases. In this review, we focus on the molecular mechanisms and potential therapeutic targets of S100A6 in tumors, nervous system diseases, leukemia, endometriosis, cardiovascular disease, osteoarthritis, and other related diseases.
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These authors contributed equally to this work.
ISSN:2218-273X
2218-273X
DOI:10.3390/biom13071139