Pattern Recognition Receptors and Inflammation

Infection of cells by microorganisms activates the inflammatory response. The initial sensing of infection is mediated by innate pattern recognition receptors (PRRs), which include Toll-like receptors, RIG-I-like receptors, NOD-like receptors, and C-type lectin receptors. The intracellular signaling...

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Bibliographic Details
Published inCell Vol. 140; no. 6; pp. 805 - 820
Main Authors Takeuchi, Osamu, Akira, Shizuo
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 19.03.2010
Subjects
Aberration
Activation
Animals
Cascades
Cytoplasm - genetics
Humans
Infection - immunology
Inflammation - immunology
Inflammatory response
Microorganisms
Pathogens
Pattern recognition
Receptors
Receptors, Pattern Recognition - immunology
Toll-Like Receptors - immunology
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Summary:Infection of cells by microorganisms activates the inflammatory response. The initial sensing of infection is mediated by innate pattern recognition receptors (PRRs), which include Toll-like receptors, RIG-I-like receptors, NOD-like receptors, and C-type lectin receptors. The intracellular signaling cascades triggered by these PRRs lead to transcriptional expression of inflammatory mediators that coordinate the elimination of pathogens and infected cells. However, aberrant activation of this system leads to immunodeficiency, septic shock, or induction of autoimmunity. In this Review, we discuss the role of PRRs, their signaling pathways, and how they control inflammatory responses.
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ISSN:0092-8674
0020-7683
1097-4172
DOI:10.1016/j.cell.2010.01.022