Associations between host characteristics and antimicrobial resistance of Salmonella Typhimurium

• Published in: Epidemiology and infection Vol. 142; no. 10; pp. 2085 - 2095
• Main Authors: RUDDAT, I., TIETZE, E., ZIEHM, D., KREIENBROCK, L.
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.10.2014
• Subjects: Adolescent; Anti-Bacterial Agents - therapeutic use; Antimicrobial resistance; Antimicrobials; Bacteria; Bacteriology; Bacteriophage Typing; Bacteriophages; beta-Lactam Resistance; Biological and medical sciences; Child; Chloramphenicol Resistance; Conurbations; Drug Resistance, Bacterial; Eggs; Feeding Behavior; Female; Fundamental and applied biological sciences. Psychology; Gastrointestinal infecrions; Gastrointestinal Infections; Geography; Germany - epidemiology; Humans; Infections; Male; Microbial Sensitivity Tests; Microbiology; Miscellaneous; Multivariate Analysis; Original Papers; P values; Predisposing factors; Risk Factors; Salmonella; Salmonella Food Poisoning - drug therapy; Salmonella Food Poisoning - epidemiology; Salmonella Infections - drug therapy; Salmonella Infections - epidemiology; Salmonella typhimurium; Salmonella typhimurium - physiology; Statistical significance; Tetracycline Resistance; Germany; epidemiological study; multivariate analysis; environment–resistance relationship; Antibiotic resistance; risk factor analysis; Resistance; Bacteria; Epidemiology; Salmonella typhimurium; Antimicrobial agent; Enterobacteriaceae
• ISSN: 0950-2688; 1469-4409
• DOI: 10.1017/S0950268813003026

A collection of Salmonella Typhimurium isolates obtained from sporadic salmonellosis cases in humans from Lower Saxony, Germany between June 2008 and May 2010 was used to perform an exploratory risk-factor analysis on antimicrobial resistance (AMR) using comprehensive host information on sociodemographic attributes, medical history, food habits and animal contact. Multivariate resistance profiles of minimum inhibitory concentrations for 13 antimicrobial agents were analysed using a non-parametric approach with multifactorial models adjusted for phage types. Statistically significant associations were observed for consumption of antimicrobial agents, region type and three factors on egg-purchasing behaviour, indicating that besides antimicrobial use the proximity to other community members, health consciousness and other lifestyle-related attributes may play a role in the dissemination of resistances. Furthermore, a statistically significant increase in AMR from the first study year to the second year was observed.