Lethal Disease in Dogs Naturally Infected with Severe Fever with Thrombocytopenia Syndrome Virus

Severe fever with the thrombocytopenia syndrome virus (SFTSV) causes fatal disease in humans, cats, and cheetahs. In this study, the information on seven dogs with SFTS was summarized. All dogs showed anorexia, high fever, leukopenia, and thrombocytopenia, two dogs showed vomiting and loose stool, a...

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Published inViruses Vol. 14; no. 9; p. 1963
Main Authors Ishijima, Keita, Tatemoto, Kango, Park, Eunsil, Kimura, Masanobu, Fujita, Osamu, Taira, Masakatsu, Kuroda, Yudai, Mendoza, Milagros Virhuez, Inoue, Yusuke, Harada, Michiko, Matsuu, Aya, Shimoda, Hiroshi, Kuwata, Ryusei, Morikawa, Shigeru, Maeda, Ken
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.09.2022
MDPI
Subjects
Animal diseases
animal hospital in Japan
Anorexia
Antibodies
Antigens
Care and treatment
Cats
Diagnosis
Disease control
Diseases
dog
Dogs
ELISA
Fever
genes
Genomes
Huaiyangshan banyangvirus
Immunoglobulin G
Immunoglobulin M
Infections
Leukopenia
Maximum likelihood method
Patient outcomes
Phylogenetics
Plasma
RT-PCR
severe fever with thrombocytopenia syndrome virus
Thrombocytopenia
ticks
Veterinary medicine
Viruses
Vomiting
zoonosis
Japan
South Korea
United States > US
China
Germany
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Summary:Severe fever with the thrombocytopenia syndrome virus (SFTSV) causes fatal disease in humans, cats, and cheetahs. In this study, the information on seven dogs with SFTS was summarized. All dogs showed anorexia, high fever, leukopenia, and thrombocytopenia, two dogs showed vomiting and loose stool, and five dogs had tick parasites. All dogs also had a history of outdoor activity. The SFTSV gene was detected in all dogs. Remarkably, three dogs (43%) died. SFTSV was isolated from six dogs and the complete genomes were determined. A significant increase in anti-SFTSV-IgG antibodies was observed in two dogs after recovery, and anti-SFTSV-IgM antibodies were detected in four dogs in the acute phase. Using an ELISA cut-off value of 0.410 to discriminate between SFTSV-negative and positive dogs, the detection of anti-SFTSV-IgM antibodies was useful for the diagnosis of dogs with acute-phase SFTS. Four out of the ninety-eight SFTSV-negative dogs possessed high anti-SFTSV IgG antibody titers, indicating that some dogs can recover from SFTSV infection. In conclusion, SFTSV is lethal in some dogs, but many dogs recover from SFTSV infection.
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ISSN:1999-4915
1999-4915
DOI:10.3390/v14091963