A new vaccine for tuberculosis in rhesus macaques

In a recent study using cytomegalovirus (CMV)-vectored vaccines in rhesus macaques, prevention of tuberculosis in over 40% of vaccinated animals is shown and is attributed to reprogrammed innate immunity and CMV's maintenance of vaccine-elicited effector memory T cells.

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Bibliographic Details
Published inNature medicine Vol. 24; no. 2; pp. 124 - 126
Main Authors Carpenter, Stephen M, Behar, Samuel M
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.02.2018
Nature Publishing Group
Subjects
631/1647/334/1874/1625
631/326/590
692/699/255/1856
Animals
Antigens
Biomarkers
Biomedicine
Cancer
Cancer Research
Cytomegalovirus
Cytomegalovirus - immunology
Development and progression
Disease prevention
Genetic aspects
Infections
Infectious Diseases
Lymphocytes
Macaca mulatta - immunology
Metabolic Diseases
Molecular Medicine
Mycobacterium tuberculosis - immunology
Neurosciences
news-and-views
Physiological aspects
Prevention
Tuberculosis
Tuberculosis - immunology
Tuberculosis vaccines
Tumor necrosis factor-TNF
Vaccines
United States
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Summary:In a recent study using cytomegalovirus (CMV)-vectored vaccines in rhesus macaques, prevention of tuberculosis in over 40% of vaccinated animals is shown and is attributed to reprogrammed innate immunity and CMV's maintenance of vaccine-elicited effector memory T cells.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Commentary-1
ISSN:1078-8956
1546-170X
DOI:10.1038/nm.4488