Impaired Glucose Transport as a Cause of Decreased Insulin-Stimulated Muscle Glycogen Synthesis in Type 2 Diabetes

• Published in: The New England journal of medicine Vol. 341; no. 4; pp. 240 - 246
• Main Authors: Cline, Gary W, Petersen, Kitt Falk, Krssak, Martin, Shen, Jun, Hundal, Ripudaman S, Trajanoski, Zlatko, Inzucchi, Silvio, Dresner, Alan, Rothman, Douglas L, Shulman, Gerald I
• Format: Journal Article
• Language: English
• Published: Boston, MA Massachusetts Medical Society 22.07.1999
• Subjects: Adult; Aged; Biological and medical sciences; Biological Transport; Blood Glucose - metabolism; Diabetes; Diabetes Mellitus, Type 2 - metabolism; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Extracellular Space - metabolism; Female; Glucose - metabolism; Glucose-6-Phosphate - metabolism; Glycogen - biosynthesis; Glycogen - metabolism; Hexokinase - metabolism; Humans; Hyperglycemia - metabolism; Hyperinsulinism - metabolism; Insulin; Insulin - metabolism; Insulin - physiology; Insulin resistance; Magnetic Resonance Spectroscopy; Male; Medical sciences; Metabolic disorders; Middle Aged; Models, Biological; Muscle, Skeletal - metabolism; Endocrinopathy; Human; Resistance; Pathogenesis; Biological transport; Alteration; Glucose; Non insulin dependent diabetes; Insulin
• ISSN: 0028-4793; 1533-4406
• DOI: 10.1056/NEJM199907223410404

Diabetes mellitus is the most common metabolic disease in the world. 1 Over 90 percent of patients with diabetes have type 2, and although the primary factors that cause this disease are unknown, it is clear that insulin resistance has an important role in its development. Evidence of this role comes from longitudinal studies showing that insulin resistance precedes the onset of the disease by 10 to 20 years, 2 – 4 from cross-sectional studies in which insulin resistance is a consistent finding in patients with type 2 diabetes, 5 – 7 and from prospective studies showing that insulin resistance is the best predictor of . . .