Dietary glycemic index, glycemic load, insulin index, fiber and whole-grain intake in relation to risk of prostate cancer

• Published in: Cancer causes & control Vol. 22; no. 1; pp. 51 - 61
• Main Authors: Nimptsch, K, Kenfield, S, Jensen, M. K, Stampfer, M. J, Franz, M, Sampson, L, Brand-Miller, J. C, Willett, W. C, Giovannucci, E
• Format: Journal Article
• Language: English
• Published: Dordrecht Dordrecht : Springer Netherlands 01.01.2011; Springer; Springer Netherlands; Springer Nature B.V
• Subjects: Adult; Aged; Biomedical and Life Sciences; Biomedicine; Cancer Research; Carbohydrates; Cohort analysis; Diabetes; Diet; Diet Surveys; Dietary carbohydrates; Dietary fiber; Dietary Fiber - metabolism; Edible Grain - metabolism; Epidemiology; Exercise; Fiber; Food; Food intake; Glucose; Glycemic index; Glycemic Index - physiology; Glycemic load; Grain; Hematology; Humans; Insulin; Insulin - metabolism; Insulin index; Insulin-like growth factors; Investigations; Lifestyles; Male; Medical personnel; Metabolism; Middle Aged; Nutrition research; Oncology; Original Paper; Prostate cancer; prostatic neoplasms; Prostatic Neoplasms - metabolism; Proteins; Public Health; Questionnaires; Risk Factors; Tumorigenesis; Whole grains; United States > US; Insulin index; Glycemic index; Whole grains; Prostate cancer; Glycemic load; Fiber
• ISSN: 0957-5243; 1573-7225
• DOI: 10.1007/s10552-010-9671-x

Objective Insulin may play a role in prostate cancer tumorigenesis. Postprandial blood glucose and insulin responses of foods depend importantly on the carbohydrate quality and quantity, represented by glycemic index (GI), glycemic load (GL), fiber and whole-grain content, but are also influenced by intake of protein and other characteristics. The recently developed insulin index (II) quantifies the postprandial insulin secretion, also taking into account these additional characteristics. Methods We investigated the association between dietary GI, GL, II, fiber, and whole grains and risk of total prostate cancer (n = 5,112) and subgroups of prostate cancer as defined by stage or grade in 49,934 male participants of the Health Professionals Follow-up Study. Multivariate adjusted hazard ratios (HR) and 95% confidence intervals (95% CI) were estimated using Cox proportional hazards regression. Results Dietary GI, GL, II, or fiber was not associated with risk of total or subgroups of prostate cancer. We observed a positive association between dietary intake of whole grains and total prostate cancer (HR highest versus lowest quintile 1.13, 95% CI 1.03-1.24), which was attenuated after restriction to PSA-screened participants (HR 1.03, 95% CI 0.91-1.17). Conclusions These results suggest that long-term exposure to a diet with a high insulin response does not affect prostate cancer incidence.