Prevalence and Prognosis of Hyperkalemia in Patients with Acute Myocardial Infarction

• Published in: The American journal of medicine Vol. 129; no. 8; pp. 858 - 865
• Main Authors: Grodzinsky, Anna, MD, MSc, Goyal, Abhinav, MD, MHS, Gosch, Kensey, MS, McCullough, Peter A., MD, MPH, Fonarow, Gregg C., MD, Mebazaa, Alexandre, MD, Masoudi, Frederick A., MD, MSPH, Spertus, John A., MD, MPH, Palmer, Biff F., MD, Kosiborod, Mikhail, MD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2016; Elsevier Sequoia S.A
• Subjects: Acute myocardial infarction; Aged; Dialysis; Female; Heart attacks; Hemodialysis; Hospital Mortality; Humans; Hyperkalemia - epidemiology; Hyperkalemia - etiology; Hyperkalemia - mortality; Hyperkalemia - therapy; Hyperkalemia prevalence; Internal Medicine; Male; Mortality; Myocardial Infarction - complications; Myocardial Infarction - mortality; Potassium; Prevalence; Prognosis; Registries; Renal Dialysis; Risk Factors; United States - epidemiology; Acute myocardial infarction; Hyperkalemia prevalence; Dialysis
• ISSN: 0002-9343; 1555-7162
• DOI: 10.1016/j.amjmed.2016.03.008

Abstract Background Hyperkalemia is common and potentially dangerous in hospitalized patients; its contemporary prevalence and prognostic importance after acute myocardial infarction are not well described. Methods In 38,689 consecutive patients with acute myocardial infarction from the Cerner Health Facts database, we evaluated the association between maximum in-hospital potassium levels and in-hospital mortality. Patients were stratified by dialysis status and grouped by maximum potassium as follows: <5 mEq/L, 5 to <5.5 mEq/L, 5.5 to <6.0 mEq/L, 6.0 to <6.5 mEq/L, and ≥6.5 mEq/L. Multivariable logistic regression was used to adjust for multiple patient and site characteristics. The relationship between the number of hyperkalemic values and the in-hospital mortality was evaluated. Results Of 38,689 patients with acute myocardial infarction, 886 were on dialysis. The rate of hyperkalemia (maximum potassium ≥5.0 mEq/L) was 22.6% in patients on dialysis and 66.8% in patients not on dialysis. Moderate to severe hyperkalemia (maximum potassium ≥5.5 mEq/L) occurred in 9.8% of patients. There was a steep increase in mortality with higher maximum potassium levels. In-hospital mortality exceeded 15% once maximum potassium was ≥5.5 mEq/L regardless of dialysis status. The relationship between higher maximum potassium and increased mortality risk persisted after multivariable adjustment. In addition, patients with a greater number of hyperkalemic values (vs a single value) experienced higher in-hospital mortality. Conclusions Hyperkalemia is common in patients who are hospitalized with acute myocardial infarction. Higher maximum potassium levels and number of hyperkalemic events are associated with a steep mortality increase, with higher risks for adverse outcomes observed even at mild levels of hyperkalemia. Whether more intensive management of hyperkalemia may improve outcomes in patients with acute myocardial infarction merits further study.