Carnosine Modulates Stress-Attenuated Plasma Antioxidative Capacity

Oral administration of carnosine (β-alanyl-L-histidine) in mice treated with restraint stress moderately alleviated a stress-induced decrease in plasma oxygen radical absorbance capacity (ORAC) activity (P = 0.075). Carnosine treatment also increased the level of plasma glutathione (GSH) and ascorbi...

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Bibliographic Details
Published inFood Science and Technology Research Vol. 15; no. 2; pp. 179 - 184
Main Authors Kurihara, Hiroshi, Shibata, Hiroshi, Tsuruoka, Nobuo, Kiso, Yoshinobu, Abe, Keiich, Nagai, Hajime, Fukami, Harukazu
Format Journal Article
LanguageEnglish
Published Tsukuba Japanese Society for Food Science and Technology 2009
Japan Science and Technology Agency
Subjects
alanine
animal models
anserine
antioxidants
ascorbic acid
beta-alanine
bioassays
blood plasma
carnosine
chemical composition
free radical scavengers
glutathione
histamine
histidine
human physiology
lipid peroxidation
mice
oxygen radical absorbance capacity
oxygen radical absorbance capacity (ORAC)
protective effect
quantitative analysis
reactive oxygen species
restraint-stress
stress tolerance
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Summary:Oral administration of carnosine (β-alanyl-L-histidine) in mice treated with restraint stress moderately alleviated a stress-induced decrease in plasma oxygen radical absorbance capacity (ORAC) activity (P = 0.075). Carnosine treatment also increased the level of plasma glutathione (GSH) and ascorbic acid compared with those in the restraint stress mice. Carnosine and related compounds anserine, histidine and histamine exhibited ORAC activity in vitro, while β-alanine was not effective. These results suggest that carnosine exerts a protective effect against the stress-induced elevation of the oxidative level in plasma.
ISSN:1344-6606
1881-3984
DOI:10.3136/fstr.15.179