Update on the Molecular Pathology of Cutaneous Squamous Cell Carcinoma

Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer, originating from keratinocytes of the spinous layer. Numerous risk factors have been discovered for the initiation and growth of this type of cancer, such as exposure to UV and ionizing radiation, chemical carcinogens, t...

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Bibliographic Details
Published inInternational journal of molecular sciences Vol. 24; no. 7; p. 6646
Main Authors Cozma, Elena-Codruta, Banciu, Laura Madalina, Soare, Cristina, Cretoiu, Sanda-Maria
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.04.2023
MDPI
Subjects
cancer stem cells
Carcinogens
Carcinoma, Squamous Cell - pathology
Care and treatment
Cell growth
Development and progression
DNA methylation
Economic impact
Epigenetic inheritance
Epigenetics
Genetic aspects
Health aspects
Humans
Immunosuppression
Immunosuppression Therapy
Immunotherapy
Impact analysis
Ionizing radiation
Keratinocytes
Keratinocytes - pathology
MicroRNAs
Molecular modelling
Mutation
Pathology
Pathology, Molecular
Radiation
Review
Risk factors
Skin
Skin cancer
Skin Neoplasms - pathology
Squamous cell carcinoma
targeted therapies
Ultraviolet radiation
Romania
skin cancer
cancer stem cells
targeted therapies
epigenetics
squamous cell carcinoma
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Summary:Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer, originating from keratinocytes of the spinous layer. Numerous risk factors have been discovered for the initiation and growth of this type of cancer, such as exposure to UV and ionizing radiation, chemical carcinogens, the presence of immunosuppression states, chronic inflammation, infections with high-risk viral strains, and, last but not least, the presence of diseases associated with genetic alterations. The important socio-economic impact, as well as the difficulty associated with therapy for advanced forms, has made the molecular mechanisms underlying this neoplasia more and more intensively studied, with the intention of achieving a better understanding and advancing the treatment of this pathology. This review aims to provide a brief foray into the molecular, genetic, and epigenetic aspects of this cancer, as well as the treatment methods, ranging from the first used to the latest targeted therapies.
Bibliography:ObjectType-Article-2
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ObjectType-Review-1
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24076646