Drug Delivery Systems for Personal Healthcare by Smart Wearable Patch System

Smart wearable patch systems that combine biosensing and therapeutic components have emerged as promising approaches for personalized healthcare and therapeutic platforms that enable self-administered, noninvasive, user-friendly, and long-acting smart drug delivery. Sensing components can continuous...

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Published inBiomolecules (Basel, Switzerland) Vol. 13; no. 6; p. 929
Main Authors Khadka, Bikram, Lee, Byeongmoon, Kim, Ki-Taek
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.06.2023
MDPI
Subjects
Analysis
Biocompatibility
Biomarkers
biosensor
Biosensors
Blood pressure
Blood vessels
Body temperature
Carbon
Data transmission
Drug delivery
Drug delivery systems
Drugs
Electrolytes
Enzymes
Glucose
Glycerol
Health care
Humidity
Hydrogels
Kinases
Liver diseases
Metabolism
Metabolites
Methods
personalized healthcare
Physiology
Polymers
Precision medicine
Review
Sensors
Skin
smart wearable patch
stimuli-responsive carriers
Transdermal medication
Triglycerides
Vehicles
Zinc oxides
South Korea
drug delivery systems
personalized healthcare
biosensor
stimuli-responsive carriers
smart wearable patch
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Summary:Smart wearable patch systems that combine biosensing and therapeutic components have emerged as promising approaches for personalized healthcare and therapeutic platforms that enable self-administered, noninvasive, user-friendly, and long-acting smart drug delivery. Sensing components can continuously monitor physiological and biochemical parameters, and the monitoring signals can be transferred to various stimuli using actuators. In therapeutic components, stimuli-responsive carrier-based drug delivery systems (DDSs) provide on-demand drug delivery in a closed-loop manner. This review provides an overview of the recent advances in smart wearable patch systems, focusing on sensing components, stimuli, and therapeutic components. Additionally, this review highlights the potential of fully integrated smart wearable patch systems for personalized medicine. Furthermore, challenges associated with the clinical applications of this system and future perspectives are discussed, including issues related to drug loading and reloading, biocompatibility, accuracy of sensing and drug delivery, and largescale fabrication.
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ISSN:2218-273X
2218-273X
DOI:10.3390/biom13060929